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Cellosaurus MCF10AT1k.cl2 (CVCL_WM98)

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Cell line name MCF10AT1k.cl2
Synonyms MCF10AT1KCl.2; MCF10AT1K
Accession CVCL_WM98
Resource Identification Initiative To cite this cell line use: MCF10AT1k.cl2 (RRID:CVCL_WM98)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Omics: Proteomics.
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5554 (MCF-10A-neoT)
Children:
CVCL_6675 (MCF10CA1a)CVCL_6677 (MCF10CA1b)CVCL_6678 (MCF10CA1c)
CVCL_6679 (MCF10CA1d)CVCL_6683 (MCF10CA1h)
Sex of cell Female
Age at sampling 36Y
Category Transformed cell line
Publications

PubMed=11261825; DOI=10.1023/A:1006461422273
Steven J. Santner, Peter J. Dawson, Larry Tait, Herbert D. Soule, James F. Eliason, Anwar N. Mohamed, Sandra R. Wolman, Gloria H. Heppner, Fred R. Miller;
Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells.
Breast Cancer Res. Treat. 65:101-110(2001)

PubMed=14523048; DOI=10.1172/JCI18899; PMCID=PMC198530
Bin-Wu Tang, Mary Vu, Timberly Booker, Steven J. Santner, Fred R. Miller, Miriam R. Anver, Lalage M. Wakefield;
TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression.
J. Clin. Invest. 112:1116-1124(2003)

PubMed=20543960; DOI=10.1371/journal.pone.0011030; PMCID=PMC2882958
Lee Yee Choong, Simin Lim, Poh Kuan Chong, Chow Yin Wong, Nilesh Shah, Yoon Pin Lim;
Proteome-wide profiling of the MCF10AT breast cancer progression model.
PLoS ONE 5:e11030.1-e11030.8(2010)

Cross-references
Encyclopedic resources Wikidata; Q95986693
Entry history
Entry creation24-May-2019
Last entry update14-Aug-2025
Version number12