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Cellosaurus MCF-7aro Let-R (CVCL_W348)

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Cell line name MCF-7aro Let-R
Synonyms MCF-7aro/LetR; MCF-7-AroR-Let-R; MCF7aroLetR; Let-R
Accession CVCL_W348
Resource Identification Initiative To cite this cell line use: MCF-7aro Let-R (RRID:CVCL_W348)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_6413; Letrozole.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:2594; CYP19A1.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_9580 (MCF-7aro)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

CLPUB00802
Erik Harris, Damir Vareslija, Jane O'Hara, Arnold D.K. Hill, Leonie S. Young;
Characterising an aromatase inhibitor-resistant breast cancer cell line.
RCSIsmj 5:97-98(2012)

DOI=10.1186/1753-6561-6-S4-P3
Erik Harris, Damir Vareslija, Jane O'Hara, Arnold D.K. Hill, Leonie S. Young;
Characterising an aromatase inhibitor resistant breast cancer cell line.
BMC Proc. 6 Suppl. 4:P3-P3(2012)

Cross-references
Cell line collections (Providers) CancerTools; 151781
Ximbio; 151781
Cell line databases/resources cancercelllines; CVCL_W348
Encyclopedic resources Wikidata; Q54904401
Entry history
Entry creation16-Apr-2014
Last entry update14-Aug-2025
Version number23