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Cellosaurus MCF-7aro (CVCL_9580)

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Cell line name MCF-7aro
Synonyms MCF-7-Aro; MCF7aro
Accession CVCL_9580
Resource Identification Initiative To cite this cell line use: MCF-7aro (RRID:CVCL_9580)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:2594; CYP19A1.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Children:
CVCL_W348 (MCF-7aro Let-R)CVCL_9581 (MCF-7aro/ERE)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=2208160
Du-Jin Zhou, Denis Pompon, Shiu-An Chen;
Stable expression of human aromatase complementary DNA in mammalian cells: a useful system for aromatase inhibitor screening.
Cancer Res. 50:6949-6954(1990)

PubMed=9449203; DOI=10.1016/S0960-0760(97)00068-X
Xiu-Zhu Sun, Du-Jin Zhou, Shiu-An Chen;
Autocrine and paracrine actions of breast tumor aromatase. A three-dimensional cell culture study involving aromatase transfected MCF-7 and T-47D cells.
J. Steroid Biochem. Mol. Biol. 63:29-36(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9580
Encyclopedic resources Wikidata; Q54904400
Experimental variables resources EFO; EFO_0002072
Entry history
Entry creation06-Jun-2012
Last entry update14-Aug-2025
Version number21