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Cellosaurus MCF-7aro/ERE (CVCL_9581)

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Cell line name MCF-7aro/ERE
Accession CVCL_9581
Resource Identification Initiative To cite this cell line use: MCF-7aro/ERE (RRID:CVCL_9581)
Comments Population: Caucasian.
Biotechnology: Can be used in an vitro assay to screen for aromatase inhibitors (AIs) at the same time as estrogen receptor alpha (Era) and ERR-alpha ligands (PubMed=18550029).
Characteristics: Expression of the luciferase gene is under the control of three repeats of estrogen responsive element (ERE) (PubMed=18550029).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:2594; CYP19A1.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_9580 (MCF-7aro)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=18550029; DOI=10.1016/j.bcp.2008.04.011; PMCID=PMC2587126
Ki Lui, Takaya Tamura, Taisuke Mori, Du-Jin Zhou, Shiu-An Chen;
MCF-7aro/ERE, a novel cell line for rapid screening of aromatase inhibitors, ERalpha ligands and ERRalpha ligands.
Biochem. Pharmacol. 76:208-215(2008)

Cross-references
Cell line databases/resources cancercelllines; CVCL_9581
Encyclopedic resources Wikidata; Q54904403
Entry history
Entry creation06-Jun-2012
Last entry update14-Aug-2025
Version number22