ID   MCF-7aro/ERE
AC   CVCL_9581
DR   cancercelllines; CVCL_9581
DR   Wikidata; Q54904403
RX   PubMed=18550029;
CC   Population: Caucasian.
CC   Biotechnology: Can be used in an vitro assay to screen for aromatase inhibitors (AIs) at the same time as estrogen receptor alpha (Era) and ERR-alpha ligands (PubMed=18550029).
CC   Characteristics: Expression of the luciferase gene is under the control of three repeats of estrogen responsive element (ERE) (PubMed=18550029).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:2594; CYP19A1.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P08659; Firefly luciferase.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_9580 ! MCF-7aro
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 21
//
RX   PubMed=18550029; DOI=10.1016/j.bcp.2008.04.011; PMCID=PMC2587126;
RA   Lui K., Tamura T., Mori T., Zhou D.-J., Chen S.-A.;
RT   "MCF-7aro/ERE, a novel cell line for rapid screening of aromatase
RT   inhibitors, ERalpha ligands and ERRalpha ligands.";
RL   Biochem. Pharmacol. 76:208-215(2008).
//