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Cellosaurus Twin-DS-iPSC (CVCL_W088)

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Cell line name Twin-DS-iPSC
Synonyms T1DS iPS
Accession CVCL_W088
Resource Identification Initiative To cite this cell line use: Twin-DS-iPSC (RRID:CVCL_W088)
Comments From: University of Geneva; Geneva; Switzerland.
Population: Caucasian.
Omics: Transcriptomics; RNAseq.
Donor information: Twin-DS-iPSC and Twin-N-iPSC (Cellosaurus=CVCL_B4L3 and CVCL_W087) originate from monozygotic twins discordant for trisomy 21.
Derived from site: In situ; Forearm, skin; UBERON=UBERON_0003403.
Cell type: Fibroblast of skin; CL=CL_0002620.
Disease Down syndrome (NCIt: C2993)
Down syndrome (ORDO: Orphanet_870)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B4L1 (Twin-DS)
Sex of cell Female
Age at sampling 16FW
Category Induced pluripotent stem cell
Publications

PubMed=24375627; DOI=10.1002/emmm.201302848; PMCID=PMC3927959
Youssef Hibaoui, Iwona Grad, Audrey Letourneau, M. Reza Sailani, Sophie Dahoun, Federico Andrea Santoni, Stefania Gimelli, Michel Guipponi, Marie-Francoise Pelte, Frederique Sloan-Bena, Stylianos E. Antonarakis, Anis Feki;
Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21.
EMBO Mol. Med. 6:259-277(2014)

PubMed=24740065; DOI=10.1038/nature13200
Audrey Letourneau, Federico Andrea Santoni, Ximena Bonilla, M. Reza Sailani, David Gonzalez, Jop Kind, Claire Chevalier, Robert Thurman, Richard S. Sandstrom, Youssef Hibaoui, Marco Garieri ...Show all 28 authors... , Konstantin Y. Popadin, Emilie Falconnet, Maryline Gagnebin, Corinne Gehrig, Anne Vannier, Michel Guipponi, Laurent Farinelli, Daniel Robyr, Eugenia Migliavacca, Christelle Borel, Samuel Deutsch, Anis Feki, John A. Stamatoyannopoulos, Yann Herault, Bas van Steensel, Roderic Guigo, Stylianos E. Antonarakis; Show fewer authors
Domains of genome-wide gene expression dysregulation in Down's syndrome.
Nature 508:345-350(2014)

Cross-references
Encyclopedic resources Wikidata; Q54973426
Gene expression databases GEO; GSM1338321
Entry history
Entry creation16-Apr-2014
Last entry update10-Apr-2025
Version number16