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Cellosaurus Twin-DS (CVCL_B4L1)

[Text version]
Cell line name Twin-DS
Synonyms T1DS
Accession CVCL_B4L1
Resource Identification Initiative To cite this cell line use: Twin-DS (RRID:CVCL_B4L1)
Comments From: University of Geneva; Geneva; Switzerland.
Population: Caucasian.
Omics: Genomics; ChIP-seq; H3K4me3.
Omics: Proteomics.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Transcriptomics; RNAseq; Single cell.
Donor information: Twin-DS and Twin-N (Cellosaurus=CVCL_B4L2) originate from monozygotic twins discordant for trisomy 21.
Derived from site: In situ; Forearm, skin; UBERON=UBERON_0003403.
Cell type: Fibroblast of skin; CL=CL_0002620.
Disease Down syndrome (NCIt: C2993)
Down syndrome (ORDO: Orphanet_870)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_W088 (Twin-DS-iPSC)
Sex of cell Female
Age at sampling 16FW
Category Finite cell line
Publications

PubMed=24375627; DOI=10.1002/emmm.201302848; PMCID=PMC3927959
Youssef Hibaoui, Iwona Grad, Audrey Letourneau, M. Reza Sailani, Sophie Dahoun, Federico Andrea Santoni, Stefania Gimelli, Michel Guipponi, Marie-Francoise Pelte, Frederique Sloan-Bena, Stylianos E. Antonarakis, Anis Feki;
Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21.
EMBO Mol. Med. 6:259-277(2014)

PubMed=24740065; DOI=10.1038/nature13200
Audrey Letourneau, Federico Andrea Santoni, Ximena Bonilla, M. Reza Sailani, David Gonzalez, Jop Kind, Claire Chevalier, Robert Thurman, Richard S. Sandstrom, Youssef Hibaoui, Marco Garieri ...Show all 28 authors... , Konstantin Y. Popadin, Emilie Falconnet, Maryline Gagnebin, Corinne Gehrig, Anne Vannier, Michel Guipponi, Laurent Farinelli, Daniel Robyr, Eugenia Migliavacca, Christelle Borel, Samuel Deutsch, Anis Feki, John A. Stamatoyannopoulos, Yann Herault, Bas van Steensel, Roderic Guigo, Stylianos E. Antonarakis; Show fewer authors
Domains of genome-wide gene expression dysregulation in Down's syndrome.
Nature 508:345-350(2014)

PubMed=28190458; DOI=10.1016/j.ajhg.2017.01.028; PMCID=PMC5339288
Federico Andrea Santoni, Georgios Stamoulis, Marco Garieri, Emilie Falconnet, Pascale Ribaux, Christelle Borel, Stylianos E. Antonarakis;
Detection of imprinted genes by single-cell allele-specific gene expression.
Am. J. Hum. Genet. 100:444-453(2017)

PubMed=30510006; DOI=10.1073/pnas.1806811115; PMCID=PMC6304968
Marco Garieri, Georgios Stamoulis, Xavier Blanc, Emilie Falconnet, Pascale Ribaux, Christelle Borel, Federico Andrea Santoni, Stylianos E. Antonarakis;
Extensive cellular heterogeneity of X inactivation revealed by single-cell allele-specific expression in human fibroblasts.
Proc. Natl. Acad. Sci. U.S.A. 115:13015-13020(2018)

Cross-references
Encyclopedic resources Wikidata; Q110433293
Gene expression databases GEO; GSE123028
GEO; GSE135500
GEO; GSM1333659
GEO; GSM1333661
GEO; GSM1338307
GEO; GSM1338308
GEO; GSM1338311
GEO; GSM1338313
GEO; GSM1338315
GEO; GSM1338317
GEO; GSM1338341
GEO; GSM1338343
Proteomic databases PRIDE; PXD004880
Entry history
Entry creation16-Dec-2021
Last entry update10-Apr-2025
Version number7