ID   Twin-DS
AC   CVCL_B4L1
SY   T1DS
DR   GEO; GSE123028
DR   GEO; GSE135500
DR   GEO; GSM1333659
DR   GEO; GSM1333661
DR   GEO; GSM1338307
DR   GEO; GSM1338308
DR   GEO; GSM1338311
DR   GEO; GSM1338313
DR   GEO; GSM1338315
DR   GEO; GSM1338317
DR   GEO; GSM1338341
DR   GEO; GSM1338343
DR   PRIDE; PXD004880
DR   Wikidata; Q110433293
RX   PubMed=24375627;
RX   PubMed=24740065;
RX   PubMed=28190458;
RX   PubMed=30510006;
CC   From: University of Geneva; Geneva; Switzerland.
CC   Population: Caucasian.
CC   Omics: Genomics; ChIP-seq; H3K4me3.
CC   Omics: Proteomics.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Transcriptomics; RNAseq; Single cell.
CC   Donor information: Twin-DS and Twin-N (Cellosaurus=CVCL_B4L2) originate from monozygotic twins discordant for trisomy 21.
CC   Derived from site: In situ; Forearm, skin; UBERON=UBERON_0003403.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C2993; Down syndrome
DI   ORDO; Orphanet_870; Down syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   16FW
CA   Finite cell line
DT   Created: 16-12-21; Last updated: 10-04-25; Version: 7
//
RX   PubMed=24375627; DOI=10.1002/emmm.201302848; PMCID=PMC3927959;
RA   Hibaoui Y., Grad I., Letourneau A., Sailani M.R., Dahoun S.,
RA   Santoni F.A., Gimelli S., Guipponi M., Pelte M.-F., Sloan-Bena F.,
RA   Antonarakis S.E., Feki A.;
RT   "Modelling and rescuing neurodevelopmental defect of Down syndrome
RT   using induced pluripotent stem cells from monozygotic twins discordant
RT   for trisomy 21.";
RL   EMBO Mol. Med. 6:259-277(2014).
//
RX   PubMed=24740065; DOI=10.1038/nature13200;
RA   Letourneau A., Santoni F.A., Bonilla X., Sailani M.R., Gonzalez D.,
RA   Kind J., Chevalier C., Thurman R., Sandstrom R.S., Hibaoui Y.,
RA   Garieri M., Popadin K.Y., Falconnet E., Gagnebin M., Gehrig C.,
RA   Vannier A., Guipponi M., Farinelli L., Robyr D., Migliavacca E.,
RA   Borel C., Deutsch S., Feki A., Stamatoyannopoulos J.A., Herault Y.,
RA   van Steensel B., Guigo R., Antonarakis S.E.;
RT   "Domains of genome-wide gene expression dysregulation in Down's
RT   syndrome.";
RL   Nature 508:345-350(2014).
//
RX   PubMed=28190458; DOI=10.1016/j.ajhg.2017.01.028; PMCID=PMC5339288;
RA   Santoni F.A., Stamoulis G., Garieri M., Falconnet E., Ribaux P.,
RA   Borel C., Antonarakis S.E.;
RT   "Detection of imprinted genes by single-cell allele-specific gene
RT   expression.";
RL   Am. J. Hum. Genet. 100:444-453(2017).
//
RX   PubMed=30510006; DOI=10.1073/pnas.1806811115; PMCID=PMC6304968;
RA   Garieri M., Stamoulis G., Blanc X., Falconnet E., Ribaux P., Borel C.,
RA   Santoni F.A., Antonarakis S.E.;
RT   "Extensive cellular heterogeneity of X inactivation revealed by
RT   single-cell allele-specific expression in human fibroblasts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 115:13015-13020(2018).
//