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Cellosaurus RIN 1046-38 (CVCL_U435)

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Cell line name RIN 1046-38
Synonyms RIN-1046-38; RIN1046-38; RINr1046-38; 1046-38; RIN-38; RIN 38
Accession CVCL_U435
Resource Identification Initiative To cite this cell line use: RIN 1046-38 (RRID:CVCL_U435)
Comments Characteristics: Secretes insulin (PubMed=1701127; PubMed=2879852).
Characteristics: Loses glucose responsiveness as well as GLUT2 and glucokinase expression with time in culture (PubMed=1701127; PubMed=8157682).
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic beta cell; CL=CL_0000169.
Disease Rat insulinoma (NCIt: C121566)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: NEDH; RS=RS_0000603.
Hierarchy Parent: CVCL_D163 (RIN-r)
Children:
CVCL_C1JK (betaG 18/3E1)CVCL_C1JU (betaG I/17)CVCL_C1KE (RIN 100/1)
CVCL_C1KF (RIN 100/2)CVCL_C1KG (RIN 100/6)CVCL_C1KH (RIN 30/10)
CVCL_C1KI (RIN 30/7)
Sex of cell Male
Age at sampling 666D
Category Cancer cell line
Web pages Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/r/cell-lines-detail-102.html
Publications

PubMed=2879852; DOI=10.1172/JCI112819; PMCID=PMC424070
Jacques Philippe, William L. Chick, Joel Francis Habener;
Multipotential phenotypic expression of genes encoding peptide hormones in rat insulinoma cell lines.
J. Clin. Invest. 79:351-358(1987)

PubMed=1701127; DOI=10.1210/endo-127-6-2779
Samuel A. Clark, Brenda L. Burnham, William L. Chick;
Modulation of glucose-induced insulin secretion from a rat clonal beta-cell line.
Endocrinology 127:2779-2788(1990)

PubMed=2284010; DOI=10.1210/mend-4-7-990
Frederick T. Fiedorek Jr., Lynn R. Carnaghi, Stephen J. Giddings;
Selective expression of the insulin I gene in rat insulinoma-derived cell lines.
Mol. Endocrinol. 4:990-999(1990)

PubMed=1505450; DOI=10.1210/endo.131.3.1505450
Frederick T. Fiedorek Jr., David Parkinson;
Carboxypeptidase H processing and secretion in rat clonal beta-cell lines.
Endocrinology 131:1054-1062(1992)

PubMed=8157682; DOI=10.1016/S0021-9258(19)78155-1
Sarah Ferber, Hector BeltrandelRio, John H. Johnson, Richard J. Noel, Laura E. Cassidy, Samuel A. Clark, Thomas C. Becker, Steven D. Hughes, Christopher Bang Newgard;
GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity.
J. Biol. Chem. 269:11523-11529(1994)

PubMed=9166666; DOI=10.2337/diab.46.6.958
Samuel A. Clark, Christian Quaade, Heba Constandy, Pernille Hansen, Philippe Alexandre Halban, Sarah Ferber, Christopher Bang Newgard, Karl Normington;
Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression.
Diabetes 46:958-967(1997)

PubMed=9166667; DOI=10.2337/diab.46.6.968
Hans-Ewald Hohmeier, Hector BeltrandelRio, Samuel A. Clark, Rosemarie Henkel-Rieger, Karl Normington, Christopher Bang Newgard;
Regulation of insulin secretion from novel engineered insulinoma cell lines.
Diabetes 46:968-977(1997)

PubMed=9549052; DOI=10.1007/BF02778148
Maria S. Rodriguez-Pena, Regina Collins, Charles Woodard, Allen M. Spiegel;
Decreased insulin content and secretion in RIN 1046-38 cells overexpressing alpha 2-adrenergic receptors.
Endocrine 7:255-260(1997)

Cross-references
Encyclopedic resources Wikidata; Q54950468
Entry history
Entry creation03-Feb-2014
Last entry update10-Apr-2025
Version number14