ID   RIN 1046-38
AC   CVCL_U435
SY   RIN-1046-38; RIN1046-38; RINr1046-38; 1046-38; RIN-38; RIN 38
DR   Wikidata; Q54950468
RX   PubMed=1505450;
RX   PubMed=1701127;
RX   PubMed=2284010;
RX   PubMed=2879852;
RX   PubMed=8157682;
RX   PubMed=9166666;
RX   PubMed=9166667;
RX   PubMed=9549052;
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/r/cell-lines-detail-102.html
CC   Characteristics: Secretes insulin (PubMed=1701127; PubMed=2879852).
CC   Characteristics: Loses glucose responsiveness as well as GLUT2 and glucokinase expression with time in culture (PubMed=1701127; PubMed=8157682).
CC   Transformant: NCIt; C17262; X-Ray.
CC   Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
CC   Cell type: Pancreatic beta cell; CL=CL_0000169.
CC   Breed/subspecies: NEDH.
DI   NCIt; C121566; Rat insulinoma
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
HI   CVCL_D163 ! RIN-r
SX   Male
AG   666D
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 29-06-23; Version: 12
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RX   PubMed=1505450; DOI=10.1210/endo.131.3.1505450;
RA   Fiedorek F.T. Jr., Parkinson D.;
RT   "Carboxypeptidase H processing and secretion in rat clonal beta-cell
RT   lines.";
RL   Endocrinology 131:1054-1062(1992).
//
RX   PubMed=1701127; DOI=10.1210/endo-127-6-2779;
RA   Clark S.A., Burnham B.L., Chick W.L.;
RT   "Modulation of glucose-induced insulin secretion from a rat clonal
RT   beta-cell line.";
RL   Endocrinology 127:2779-2788(1990).
//
RX   PubMed=2284010; DOI=10.1210/mend-4-7-990;
RA   Fiedorek F.T. Jr., Carnaghi L.R., Giddings S.J.;
RT   "Selective expression of the insulin I gene in rat insulinoma-derived
RT   cell lines.";
RL   Mol. Endocrinol. 4:990-999(1990).
//
RX   PubMed=2879852; DOI=10.1172/JCI112819;
RA   Philippe J., Chick W.L., Habener J.F.;
RT   "Multipotential phenotypic expression of genes encoding peptide
RT   hormones in rat insulinoma cell lines.";
RL   J. Clin. Invest. 79:351-358(1987).
//
RX   PubMed=8157682; DOI=10.1016/S0021-9258(19)78155-1;
RA   Ferber S., BeltrandelRio H., Johnson J.H., Noel R.J., Cassidy L.E.,
RA   Clark S.A., Becker T.C., Hughes S.D., Newgard C.B.;
RT   "GLUT-2 gene transfer into insulinoma cells confers both low and high
RT   affinity glucose-stimulated insulin release. Relationship to
RT   glucokinase activity.";
RL   J. Biol. Chem. 269:11523-11529(1994).
//
RX   PubMed=9166666; DOI=10.2337/diab.46.6.958;
RA   Clark S.A., Quaade C., Constandy H., Hansen P., Halban P.A., Ferber S.,
RA   Newgard C.B., Normington K.;
RT   "Novel insulinoma cell lines produced by iterative engineering of
RT   GLUT2, glucokinase, and human insulin expression.";
RL   Diabetes 46:958-967(1997).
//
RX   PubMed=9166667; DOI=10.2337/diab.46.6.968;
RA   Hohmeier H.-E., BeltrandelRio H., Clark S.A., Henkel-Rieger R.,
RA   Normington K., Newgard C.B.;
RT   "Regulation of insulin secretion from novel engineered insulinoma cell
RT   lines.";
RL   Diabetes 46:968-977(1997).
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RX   PubMed=9549052; DOI=10.1007/BF02778148;
RA   Rodriguez-Pena M.S., Collins R., Woodard C., Spiegel A.M.;
RT   "Decreased insulin content and secretion in RIN 1046-38 cells
RT   overexpressing alpha 2-adrenergic receptors.";
RL   Endocrine 7:255-260(1997).
//