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Cellosaurus betaG I/17 (CVCL_C1JU)

[Text version]
Cell line name betaG I/17
Synonyms betaG 1/17; BG I/17
Accession CVCL_C1JU
Resource Identification Initiative To cite this cell line use: betaG I/17 (RRID:CVCL_C1JU)
Comments Characteristics: Transfected with a pCB6-INS-Neo construct. Expresses 10 times more insulin than the parent cell line (PubMed=9166666).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6081; INS.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic beta cell; CL=CL_0000169.
Disease Rat insulinoma (NCIt: C121566)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: NEDH; RS=RS_0000603.
Hierarchy Parent: CVCL_U435 (RIN 1046-38)
Children:
CVCL_C1JV (betaG 11/3E9)CVCL_C1JW (betaG 23/21)CVCL_C1JX (betaG 40/107)
CVCL_C1JZ (betaG 40/110)
Sex of cell Male
Age at sampling 666D
Category Cancer cell line
Publications

PubMed=9166666; DOI=10.2337/diab.46.6.958
Samuel A. Clark, Christian Quaade, Heba Constandy, Pernille Hansen, Philippe Alexandre Halban, Sarah Ferber, Christopher Bang Newgard, Karl Normington;
Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression.
Diabetes 46:958-967(1997)

PubMed=9166667; DOI=10.2337/diab.46.6.968
Hans-Ewald Hohmeier, Hector BeltrandelRio, Samuel A. Clark, Rosemarie Henkel-Rieger, Karl Normington, Christopher Bang Newgard;
Regulation of insulin secretion from novel engineered insulinoma cell lines.
Diabetes 46:968-977(1997)

Cross-references
Encyclopedic resources Wikidata; Q114310746
Entry history
Entry creation22-Sep-2022
Last entry update14-Aug-2025
Version number8