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Cellosaurus betaG 11/3E9 (CVCL_C1JV)

[Text version]
Cell line name betaG 11/3E9
Synonyms betaG11/3E9
Accession CVCL_C1JV
Resource Identification Initiative To cite this cell line use: betaG 11/3E9 (RRID:CVCL_C1JV)
Comments Characteristics: Transfected with both a pCB6-INS-Neo and a pRIP7-INS-HygroR constructs. Expresses 27 times more insulin than the grand-parent cell line (PubMed=9166666).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6081; INS.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic beta cell; CL=CL_0000169.
Disease Rat insulinoma (NCIt: C121566)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: NEDH; RS=RS_0000603.
Hierarchy Parent: CVCL_C1JU (betaG I/17)
Sex of cell Male
Age at sampling 666D
Category Cancer cell line
Publications

PubMed=9166666; DOI=10.2337/diab.46.6.958
Samuel A. Clark, Christian Quaade, Heba Constandy, Pernille Hansen, Philippe Alexandre Halban, Sarah Ferber, Christopher Bang Newgard, Karl Normington;
Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression.
Diabetes 46:958-967(1997)

Cross-references
Encyclopedic resources Wikidata; Q114310739
Entry history
Entry creation22-Sep-2022
Last entry update14-Aug-2025
Version number9