ID   betaG 11/3E9
AC   CVCL_C1JV
SY   betaG11/3E9
DR   Wikidata; Q114310739
RX   PubMed=9166666;
CC   Characteristics: Transfected with both a pCB6-INS-Neo and a pRIP7-INS-HygroR constructs. Expresses 27 times more insulin than the grand-parent cell line (PubMed=9166666).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6081; INS.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCIt; C17262; X-Ray.
CC   Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
CC   Cell type: Pancreatic beta cell; CL=CL_0000169.
CC   Breed/subspecies: NEDH; RS=RS_0000603.
DI   NCIt; C121566; Rat insulinoma
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
HI   CVCL_C1JU ! betaG I/17
SX   Male
AG   666D
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 10-04-25; Version: 8
//
RX   PubMed=9166666; DOI=10.2337/diab.46.6.958;
RA   Clark S.A., Quaade C., Constandy H., Hansen P., Halban P.A., Ferber S.,
RA   Newgard C.B., Normington K.;
RT   "Novel insulinoma cell lines produced by iterative engineering of
RT   GLUT2, glucokinase, and human insulin expression.";
RL   Diabetes 46:958-967(1997).
//