Cellosaurus cell line MDCK-MDR1 (CVCL

Cellosaurus MDCK-MDR1 (CVCL_S586)

Cross-references
Cell line name	MDCK-MDR1
Synonyms	MDCK MDR1; MDCKII-MRP1; MDCKII-MDR1; MDCK2-MDR1; MDCKII x ABCB1-Neo
Accession	CVCL_S586
Resource Identification Initiative	To cite this cell line use: MDCK-MDR1 (RRID:CVCL_S586)
Comments	Genetic integration: Method=Transfection; Gene=HGNC; HGNC:40; ABCB1. Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Caution: There is another MDCK-II cell line with transfected human ABCB1: MDCK2-ABCB1 (Cellosaurus=CVCL_A2JZ). Derived from site: In situ; Kidney; UBERON=UBERON_0002113. Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin	Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615) Breed/subspecies: Cocker Spaniel; VBO=VBO_0200372.
Hierarchy	Parent: CVCL_0424 (MDCK-II)
Sex of cell	Female
Age at sampling	Adult
Category	Spontaneously immortalized cell line
Web pages	Provider; Creative Cell; -; https://www.creativecell.hu/cell-line_rtu_abc.html
Publications	PubMed=9426231; DOI=10.1016/S0014-5793(97)01442-7 Raymond Evers, Nicole H.P. Cnubben, Jan Wijnholds, Liesbeth van Deemter, Peter J. van Bladeren, Piet Borst; Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1. FEBS Lett. 419:112-116(1997) PubMed=12134945; DOI=10.1023/A:1016140429238 Fu-Xing Tang, Kazutoshi Horie, Ronald T. Borchardt; Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? Pharm. Res. 19:765-772(2002) PubMed=16749865; DOI=10.1021/mp0500768; PMCID=PMC2553563 Shuang-Hui Luo, Viral S. Kansara, Xiao-Dong Zhu, Nanda K. Mandava, Dhananjay Pal, Ashim K. Mitra; Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery. Mol. Pharm. 3:329-339(2006) PubMed=21766308; DOI=10.1002/jps.22674 Li Di, Carrie Whitney-Pickett, John P. Umland, Hui Zhang, Xun Zhang, David F. Gebhard, Yu-Rong Lai, James J. Federico 3rd, Ralph E. Davidson, Russ Smith, Eric L. Reyner ...Show all 20 authors... , Caroline Lee, Bo Feng, Charles Rotter, Manthena V. Varma, Sarah Kempshall, Katherine Fenner, Ayman F. El-Kattan, Theodore E. Liston, Matthew D. Troutman; Show fewer authors Development of a new permeability assay using low-efflux MDCKII cells. J. Pharm. Sci. 100:4974-4985(2011)
Anatomy/cell type resources	BTO; BTO_0005423
Chemistry resources	ChEMBL-Cells; CHEMBL4295482 ChEMBL-Targets; CHEMBL4296467 PubChem_Cell_line; CVCL_S586
Encyclopedic resources	Wikidata; Q54904783
Entry history
Entry creation	03-Feb-2014
Last entry update	14-Aug-2025
Version number	21