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Cellosaurus MDCK-MDR1 (CVCL_S586)

[Text version]
Cell line name MDCK-MDR1
Accession CVCL_S586
Resource Identification Initiative To cite this cell line use: MDCK-MDR1 (RRID:CVCL_S586)
Comments Transfected with: HGNC; 40; ABCB1.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Caution: There is another MDCK-II cell line with transfected human ABCB1: MDCK2-ABCB1 (Cellosaurus=CVCL_A2JZ).
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Cocker Spaniel.
Hierarchy Parent: CVCL_0424 (MDCK-II)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Web pages http://www.creativecell.hu/cell-line_rtu_abc.html

PubMed=9426231; DOI=10.1016/S0014-5793(97)01442-7
Evers R., Cnubben N.H.P., Wijnholds J., van Deemter L., van Bladeren P.J., Borst P.
Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1.
FEBS Lett. 419:112-116(1997)

PubMed=12134945; DOI=10.1023/A:1016140429238
Tang F.-X., Horie K., Borchardt R.T.
Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?
Pharm. Res. 19:765-772(2002)

PubMed=16749865; DOI=10.1021/mp0500768
Luo S., Kansara V.S., Zhu X., Mandava N.K., Pal D., Mitra A.K.
Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery.
Mol. Pharm. 3:329-339(2006)

PubMed=21766308; DOI=10.1002/jps.22674
Di L., Whitney-Pickett C., Umland J.P., Zhang H., Zhang X., Gebhard D.F., Lai Y.-R., Federico J.J. III, Davidson R.E., Smith R., Reyner E.L., Lee C., Feng B., Rotter C., Varma M.V., Kempshall S., Fenner K., El-Kattan A.F., Liston T.E., Troutman M.D.
Development of a new permeability assay using low-efflux MDCKII cells.
J. Pharm. Sci. 100:4974-4985(2011)

Anatomy/cell type resources BTO; BTO:0005423
Chemistry resources ChEMBL-Cells; CHEMBL4295482
ChEMBL-Targets; CHEMBL4296467
PubChem_Cell_line; CVCL_S586
Encyclopedic resources Wikidata; Q54904783
Entry history
Entry creation03-Feb-2014
Last entry update05-Oct-2023
Version number17