ID   MDCK-MDR1
AC   CVCL_S586
SY   MDCK MDR1; MDCKII-MRP1; MDCKII-MDR1; MDCK2-MDR1; MDCKII x ABCB1-Neo
DR   BTO; BTO_0005423
DR   ChEMBL-Cells; CHEMBL4295482
DR   ChEMBL-Targets; CHEMBL4296467
DR   PubChem_Cell_line; CVCL_S586
DR   Wikidata; Q54904783
RX   PubMed=9426231;
RX   PubMed=12134945;
RX   PubMed=16749865;
RX   PubMed=21766308;
WW   Provider; Creative Cell; -; https://www.creativecell.hu/cell-line_rtu_abc.html
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:40; ABCB1.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Caution: There is another MDCK-II cell line with transfected human ABCB1: MDCK2-ABCB1 (Cellosaurus=CVCL_A2JZ).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
CC   Cell type: Epithelial cell of kidney; CL=CL_0002518.
CC   Breed/subspecies: Cocker Spaniel; VBO=VBO_0200372.
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
HI   CVCL_0424 ! MDCK-II
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 03-02-14; Last updated: 10-04-25; Version: 20
//
RX   PubMed=9426231; DOI=10.1016/S0014-5793(97)01442-7;
RA   Evers R., Cnubben N.H.P., Wijnholds J., van Deemter L.,
RA   van Bladeren P.J., Borst P.;
RT   "Transport of glutathione prostaglandin A conjugates by the multidrug
RT   resistance protein 1.";
RL   FEBS Lett. 419:112-116(1997).
//
RX   PubMed=12134945; DOI=10.1023/A:1016140429238;
RA   Tang F.-X., Horie K., Borchardt R.T.;
RT   "Are MDCK cells transfected with the human MDR1 gene a good model of
RT   the human intestinal mucosa?";
RL   Pharm. Res. 19:765-772(2002).
//
RX   PubMed=16749865; DOI=10.1021/mp0500768; PMCID=PMC2553563;
RA   Luo S.-H., Kansara V.S., Zhu X.-D., Mandava N.K., Pal D., Mitra A.K.;
RT   "Functional characterization of sodium-dependent multivitamin
RT   transporter in MDCK-MDR1 cells and its utilization as a target for
RT   drug delivery.";
RL   Mol. Pharm. 3:329-339(2006).
//
RX   PubMed=21766308; DOI=10.1002/jps.22674;
RA   Di L., Whitney-Pickett C., Umland J.P., Zhang H., Zhang X.,
RA   Gebhard D.F., Lai Y.-R., Federico J.J. 3rd, Davidson R.E., Smith R.,
RA   Reyner E.L., Lee C., Feng B., Rotter C., Varma M.V., Kempshall S.,
RA   Fenner K., El-Kattan A.F., Liston T.E., Troutman M.D.;
RT   "Development of a new permeability assay using low-efflux MDCKII
RT   cells.";
RL   J. Pharm. Sci. 100:4974-4985(2011).
//