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Cellosaurus KKU-213A (CVCL_M261)

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Cell line name KKU-213A
Synonyms KKU-M213; KKUM213; M213; KKU-213; KKU213
Accession CVCL_M261
Resource Identification Initiative To cite this cell line use: KKU-213A (RRID:CVCL_M261)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Southeast Asian; Thai.
Doubling time: 23.3 +- 0.8 hours (PubMed=32207095); 23.4 hours (PubMed=27461717).
Karyotypic information: Has lost chromosome Y.
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Caution: After JCRB found out that KKU-M156 and KKU-M214 were derived from KKU-M213, these three cell lines were renamed by the lab which established them: KKU-M213 became KKU-213A, KKU-M214 became KKU-M213B and KKU-M156 became KKU-M213C (PubMed=32207095).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Cys (c.37G>T); ClinVar=VCV000045123; Zygosity=Unspecified (DepMap=ACH-001538).
Disease Intrahepatic cholangiocarcinoma (NCIt: C35417)
Opisthorchis viverrini-related cholangiocarcinoma (NCIt: C27769)
Cholangiocarcinoma (ORDO: Orphanet_70567)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_M264 (KKU-213B)CVCL_M260 (KKU-213C)CVCL_C6MZ (KKU-213L5)
CVCL_M262 (KKU-M213L0H)CVCL_M263 (KKU-M213L5H)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001538; JCRB=JCRB1557; PubMed=32207095

FGA16 (DepMap=ACH-001538)
16,19 (PubMed=32207095)
Penta D9
Penta E11

Run an STR similarity search on this cell line

PubMed=20493868; DOI=10.1016/j.ijpara.2010.05.002
Yonglitthipagon P., Pairojkul C., Chamgramol Y., Mulvenna J., Sripa B.
Up-regulation of annexin A2 in cholangiocarcinoma caused by Opisthorchis viverrini and its implication as a prognostic marker.
Int. J. Parasitol. 40:1203-1212(2010)

PubMed=21871105; DOI=10.1186/1476-4598-10-102
Obchoei S., Weakley S.M., Wongkham S., Wongkham C., Sawanyawisuth K., Yao Q.-Z., Chen C.-Y.
Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma.
Mol. Cancer 10:102.1-102.15(2011)

PubMed=22926522; DOI=10.1038/onc.2012.382
Kunkeaw N., Jeon S.H., Lee K., Johnson B.H., Tanasanvimon S., Javle M., Pairojkul C., Chamgramol Y., Wongfieng W., Gong B., Leelayuwat C., Lee Y.S.
Cell death/proliferation roles for nc886, a non-coding RNA, in the protein kinase R pathway in cholangiocarcinoma.
Oncogene 32:3722-3731(2013)

PubMed=27461717; DOI=10.3892/or.2016.4974
Uthaisar K., Vaeteewoottacharn K., Seubwai W., Talabnin C., Sawanyawisuth K., Obchoei S., Kraiklang R., Okada S., Wongkham S.
Establishment and characterization of a novel human cholangiocarcinoma cell line with high metastatic activity.
Oncol. Rep. 36:1435-1446(2016)

PubMed=31077409; DOI=10.1002/hep.30704
Sittithumcharee G., Suppramote O., Vaeteewoottacharn K., Sirisuksakun C., Jamnongsong S., Laphanuwat P., Suntiparpluacha M., Matha A., Chusorn P., Buraphat P., Kakanaporn C., Charngkaew K., Silsirivanit A., Korphaisarn K., Limsrichamrern S., Tripatara P., Pairojkul C., Wongkham S., Sampattavanich S., Okada S., Jirawatnotai S.
Dependency of cholangiocarcinoma on cyclin D-dependent kinase activity.
Hepatology 70:1614-1630(2019)

PubMed=32207095; DOI=10.1007/s13577-020-00334-w
Sripa B., Seubwai W., Vaeteewoottacharn K., Sawanyawisuth K., Silsirivanit A., Kaewkong W., Muisuk K., Dana P., Phoomak C., Lert-itthiporn W., Luvira V., Pairojkul C., Teh B.T., Wongkham S., Okada S., Chamgramol Y.
Functional and genetic characterization of three cell lines derived from a single tumor of an Opisthorchis viverrini-associated cholangiocarcinoma patient.
Hum. Cell 33:695-708(2020)

PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007
Isidan A., Yenigun A., Soma D., Aksu E., Lopez K., Park Y., Cross-Najafi A., Li P., Kundu D., House M.G., Chakraborty S., Glaser S., Kennedy L., Francis H., Zhang W.-J., Alpini G.D., Ekser B.
Development and characterization of human primary cholangiocarcinoma cell lines.
Am. J. Pathol. 192:1200-1217(2022)

Cell line collections (Providers) JCRB; JCRB1557
Cell line databases/resources cancercelllines; CVCL_M261
Cell_Model_Passport; SIDM01801
DepMap; ACH-001538
Encyclopedic resources Wikidata; Q54900008
Entry history
Entry creation05-Nov-2013
Last entry update02-May-2024
Version number20