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Cellosaurus KKU-213B (CVCL_M264)

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Cell line name KKU-213B
Synonyms KKU-M214; KKUM214; M214; KKU-214; KKU214; Khon Kaen University-M214
Accession CVCL_M264
Resource Identification Initiative To cite this cell line use: KKU-213B (RRID:CVCL_M264)
Comments Problematic cell line: Contaminated. Shown to be a KKU-213A derivative (PubMed=32207095 and JCRB web site).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00592.
Population: Southeast Asian; Thai.
Doubling time: 22.68 +- 2.20 hours (PubMed=25998688); 24.5 +- 0.2 hours (PubMed=32207095).
Karyotypic information: Has lost chromosome Y.
Omics: Transcriptomics; Microarray.
Caution: After JCRB found out that KKU-M156 and KKU-M214 were derived from KKU-M213, these three cell lines were renamed by the lab which established them: KKU-M213 became KKU-213A, KKU-M214 became KKU-M213B and KKU-M156 became KKU-M213C (PubMed=32207095).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Cys (c.37G>T); ClinVar=VCV000045123; Zygosity=Unspecified (from parent cell line).
Disease Intrahepatic cholangiocarcinoma (NCIt: C35417)
Opisthorchis viverrini-related cholangiocarcinoma (NCIt: C27769)
Cholangiocarcinoma (ORDO: Orphanet_70567)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_M261 (KKU-213A)
Children:
CVCL_C1L6 (KKU-M214/246)CVCL_C1L7 (KKU-M214/9)CVCL_HF58 (KKU-M214/GEM)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): PubMed=32207095

Markers:
AmelogeninX
CSF1PO9,13
D2S133822,23,24
D3S135815
D5S8189
D7S82011
D8S117911,13
D13S3178,12
D16S5399,11
D18S5114
D19S43313,14
D21S1129
FGA16,19
TH017
TPOX8
vWA18

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=15884115; DOI=10.3748/wjg.v11.i18.2748; PMCID=PMC4305909
Nisana Tepsiri, Liengchai Chaturat, Banchob Sripa, Wises Namwat, Sopit Wongkham, Vajarabhongsa Bhudhisawasdi, Wichittra Tassaneeyakul;
Drug sensitivity and drug resistance profiles of human intrahepatic cholangiocarcinoma cell lines.
World J. Gastroenterol. 11:2748-2753(2005)

PubMed=16475706
Tasanee Panichakul, Pakamas Intachote, Adisak Wongkajornsilp, Banchob Sripa, Stitaya Sirisinha;
Triptolide sensitizes resistant cholangiocarcinoma cells to TRAIL-induced apoptosis.
Anticancer Res. 26:259-265(2006)

PubMed=18714155; DOI=10.1159/000151541
Nisana Namwat, Piyawan Amimanan, Watcharin Loilome, Patcharee Jearanaikoon, Banchob Sripa, Vajarabhongsa Bhudhisawasdi, Wichittra Tassaneeyakul;
Characterization of 5-fluorouracil-resistant cholangiocarcinoma cell lines.
Chemotherapy 54:343-351(2008)

PubMed=21871105; DOI=10.1186/1476-4598-10-102; PMCID=PMC3173387
Sumalee Obchoei, Sarah M. Weakley, Sopit Wongkham, Chaisiri Wongkham, Kanlayanee Sawanyawisuth, Qi-Zhi Yao, Chang-Yi Chen;
Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma.
Mol. Cancer 10:102.1-102.15(2011)

PubMed=22926522; DOI=10.1038/onc.2012.382; PMCID=PMC3869796
Nawapol Kunkeaw, Sung Ho Jeon, Kwanbok Lee, Betty H. Johnson, Suebpong Tanasanvimon, Milind Javle, Chawalit Pairojkul, Yaovalux Chamgramol, Wipaporn Wongfieng, Bin Gong, Chanwit Leelayuwat, Yung Sun Lee;
Cell death/proliferation roles for nc886, a non-coding RNA, in the protein kinase R pathway in cholangiocarcinoma.
Oncogene 32:3722-3731(2013)

PubMed=25998688; DOI=10.3892/ijo.2015.3019
Wareeporn Wattanawongdon, Chariya Hahnvajanawong, Nisana Namwat, Sirimas Kanchanawat, Thidarut Boonmars, Patcharee Jearanaikoon, Chanwit Leelayuwat, Anchalee Techasen, Wunchana Seubwai;
Establishment and characterization of gemcitabine-resistant human cholangiocarcinoma cell lines with multidrug resistance and enhanced invasiveness.
Int. J. Oncol. 47:398-410(2015)

PubMed=31077409; DOI=10.1002/hep.30704
Gunya Sittithumcharee, Orawan Suppramote, Kulthida Vaeteewoottacharn, Chumphon Sirisuksakun, Supawan Jamnongsong, Phatthamon Laphanuwat, Monthira Suntiparpluacha, Arriya Matha, Porncheera Chusorn, Pongsakorn Buraphat, Chumpot Kakanaporn ...Show all 21 authors... , Komgrid Charngkaew, Atit Silsirivanit, Krittiya Korphaisarn, Somchai Limsrichamrern, Pinpat Tripatara, Chawalit Pairojkul, Sopit Wongkham, Somponnat Sampattavanich, Seiji Okada, Siwanon Jirawatnotai; Show fewer authors
Dependency of cholangiocarcinoma on cyclin D-dependent kinase activity.
Hepatology 70:1614-1630(2019)

PubMed=32207095; DOI=10.1007/s13577-020-00334-w
Banchob Sripa, Wunchana Seubwai, Kulthida Vaeteewoottacharn, Kanlayanee Sawanyawisuth, Atit Silsirivanit, Worasak Kaewkong, Kanha Muisuk, Paweena Dana, Chatchai Phoomak, Worachart Lert-itthiporn, Vor Luvira ...Show all 16 authors... , Chawalit Pairojkul, Bin Tean Teh, Sopit Wongkham, Seiji Okada, Yaovalux Chamgramol; Show fewer authors
Functional and genetic characterization of three cell lines derived from a single tumor of an Opisthorchis viverrini-associated cholangiocarcinoma patient.
Hum. Cell 33:695-708(2020)

PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007; PMCID=PMC9472155
Abdulkadir Isidan, Ali Yenigun, Daiki Soma, Eric Aksu, Kevin Lopez, Yujin Park, Arthur Cross-Najafi, Ping Li, Debjyoti Kundu, Michael G. House, Sanjukta Chakraborty ...Show all 17 authors... , Shannon Glaser, Lindsey Kennedy, Heather Francis, Wen-Jun Zhang, Gianfranco D. Alpini, Burcin Ekser; Show fewer authors
Development and characterization of human primary cholangiocarcinoma cell lines.
Am. J. Pathol. 192:1200-1217(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB1556 - Discontinued
Encyclopedic resources Wikidata; Q54900011
Entry history
Entry creation05-Nov-2013
Last entry update10-Apr-2025
Version number20