ID   KKU-213A
AC   CVCL_M261
SY   KKU-M213; KKUM213; M213; KKU-213; KKU213
DR   cancercelllines; CVCL_M261
DR   Cell_Model_Passport; SIDM01801
DR   DepMap; ACH-001538
DR   JCRB; JCRB1557
DR   Wikidata; Q54900008
RX   PubMed=20493868;
RX   PubMed=21871105;
RX   PubMed=22926522;
RX   PubMed=27461717;
RX   PubMed=31077409;
RX   PubMed=32207095;
RX   PubMed=35640676;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Southeast Asian; Thai.
CC   Doubling time: 23.3 +- 0.8 hours (PubMed=32207095); 23.4 hours (PubMed=27461717).
CC   Karyotypic information: Has lost chromosome Y.
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Cys (c.37G>T); ClinVar=VCV000045123; Zygosity=Unspecified (DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Caution: After JCRB found out that KKU-M156 and KKU-M214 were derived from KKU-M213, these three cell lines were renamed by the lab which established them: KKU-M213 became KKU-213A, KKU-M214 became KKU-M213B and KKU-M156 became KKU-M213C (PubMed=32207095).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
ST   Source(s): DepMap; JCRB; PubMed=32207095
ST   Amelogenin: X
ST   CSF1PO: 9,13
ST   D13S317: 8,12
ST   D16S539: 9,11
ST   D18S51: 14
ST   D19S433: 13,14
ST   D21S11: 29
ST   D2S1338: 24
ST   D3S1358: 15
ST   D5S818: 9
ST   D7S820: 11
ST   D8S1179: 11,13
ST   FGA: 16 (DepMap)
ST   FGA: 16,19 (PubMed=32207095)
ST   Penta D: 9
ST   Penta E: 11
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 18
DI   NCIt; C35417; Intrahepatic cholangiocarcinoma
DI   NCIt; C27769; Opisthorchis viverrini-related cholangiocarcinoma
DI   ORDO; Orphanet_70567; Cholangiocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 05-10-23; Version: 19
//
RX   PubMed=20493868; DOI=10.1016/j.ijpara.2010.05.002;
RA   Yonglitthipagon P., Pairojkul C., Chamgramol Y., Mulvenna J.,
RA   Sripa B.;
RT   "Up-regulation of annexin A2 in cholangiocarcinoma caused by
RT   Opisthorchis viverrini and its implication as a prognostic marker.";
RL   Int. J. Parasitol. 40:1203-1212(2010).
//
RX   PubMed=21871105; DOI=10.1186/1476-4598-10-102;
RA   Obchoei S., Weakley S.M., Wongkham S., Wongkham C., Sawanyawisuth K.,
RA   Yao Q.-Z., Chen C.-Y.;
RT   "Cyclophilin A enhances cell proliferation and tumor growth of liver
RT   fluke-associated cholangiocarcinoma.";
RL   Mol. Cancer 10:102.1-102.15(2011).
//
RX   PubMed=22926522; DOI=10.1038/onc.2012.382;
RA   Kunkeaw N., Jeon S.H., Lee K., Johnson B.H., Tanasanvimon S.,
RA   Javle M., Pairojkul C., Chamgramol Y., Wongfieng W., Gong B.,
RA   Leelayuwat C., Lee Y.S.;
RT   "Cell death/proliferation roles for nc886, a non-coding RNA, in the
RT   protein kinase R pathway in cholangiocarcinoma.";
RL   Oncogene 32:3722-3731(2013).
//
RX   PubMed=27461717; DOI=10.3892/or.2016.4974;
RA   Uthaisar K., Vaeteewoottacharn K., Seubwai W., Talabnin C.,
RA   Sawanyawisuth K., Obchoei S., Kraiklang R., Okada S., Wongkham S.;
RT   "Establishment and characterization of a novel human
RT   cholangiocarcinoma cell line with high metastatic activity.";
RL   Oncol. Rep. 36:1435-1446(2016).
//
RX   PubMed=31077409; DOI=10.1002/hep.30704;
RA   Sittithumcharee G., Suppramote O., Vaeteewoottacharn K.,
RA   Sirisuksakun C., Jamnongsong S., Laphanuwat P., Suntiparpluacha M.,
RA   Matha A., Chusorn P., Buraphat P., Kakanaporn C., Charngkaew K.,
RA   Silsirivanit A., Korphaisarn K., Limsrichamrern S., Tripatara P.,
RA   Pairojkul C., Wongkham S., Sampattavanich S., Okada S.,
RA   Jirawatnotai S.;
RT   "Dependency of cholangiocarcinoma on cyclin D-dependent kinase
RT   activity.";
RL   Hepatology 70:1614-1630(2019).
//
RX   PubMed=32207095; DOI=10.1007/s13577-020-00334-w;
RA   Sripa B., Seubwai W., Vaeteewoottacharn K., Sawanyawisuth K.,
RA   Silsirivanit A., Kaewkong W., Muisuk K., Dana P., Phoomak C.,
RA   Lert-itthiporn W., Luvira V., Pairojkul C., Teh B.T., Wongkham S.,
RA   Okada S., Chamgramol Y.;
RT   "Functional and genetic characterization of three cell lines derived
RT   from a single tumor of an Opisthorchis viverrini-associated
RT   cholangiocarcinoma patient.";
RL   Hum. Cell 33:695-708(2020).
//
RX   PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007;
RA   Isidan A., Yenigun A., Soma D., Aksu E., Lopez K., Park Y.,
RA   Cross-Najafi A., Li P., Kundu D., House M.G., Chakraborty S.,
RA   Glaser S., Kennedy L., Francis H., Zhang W.-J., Alpini G.D., Ekser B.;
RT   "Development and characterization of human primary cholangiocarcinoma
RT   cell lines.";
RL   Am. J. Pathol. 192:1200-1217(2022).
//