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Cellosaurus H-STS (CVCL_L296)

[Text version]
Cell line name H-STS
Synonyms HSTS
Accession CVCL_L296
Resource Identification Initiative To cite this cell line use: H-STS (RRID:CVCL_L296)
Comments Problematic cell line: Misclassified. Originally thought to arise from a metastatic carcinoid of the terminal ileum but shown to be an EBV-transformed lymphoblastoid cell line (PubMed=29444910; PubMed=31548718). Although misidentified, it has been argued that transcriptional regulation of the cells enough resemble gastroenteropancreatic neuroendocrine tumors to be used in studies (PubMed=31548719).
Doubling time: ~3 days (PubMed=19528452).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Variations; SNP array analysis.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_L297 ! L-STS
CVCL_L298 ! P-STS
Sex of cell Male
Age at sampling 42Y
Category Transformed cell line
STR profile Source(s): PubMed=29444910

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81811
D7S82010,12
D13S3178,14
D16S53913
D21S1128,30
TH019,9.3
TPOX8
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=19528452
Pfragner R., Behmel A., Hoger H., Beham A., Ingolic E., Stelzer I., Svejda B., Moser V.A., Obenauf A.C., Siegl V., Haas O.A., Niederle B.
Establishment and characterization of three novel cell lines -- P-STS, L-STS, H-STS -- derived from a human metastatic midgut carcinoid.
Anticancer Res. 29:1951-1961(2009)

PubMed=29444910; DOI=10.1530/ERC-17-0445; PMCID=PMC5827037
Hofving T., Arvidsson Y., Almobarak B., Inge L., Pfragner R., Persson M., Stenman G., Kristiansson E., Johanson V., Nilsson O.
The neuroendocrine phenotype, genomic profile and therapeutic sensitivity of GEPNET cell lines.
Endocr. Relat. Cancer 25:367-380(2018)

PubMed=31548718; DOI=10.1038/s41588-019-0490-z
Hofving T., Karlsson J.W., Nilsson O., Nilsson J.A.
H-STS, L-STS and KRJ-I are not authentic GEPNET cell lines.
Nat. Genet. 51:1426-1427(2019)

PubMed=31548719; DOI=10.1038/s41588-019-0509-5; PMCID=PMC7256901
Alvarez M.J., Yan P.-R., Alpaugh M.L., Bowden M., Sicinska E.T., Zhou C.-S.W., Karan C., Realubit R.B., Mundi P.S., Grunn A., Jager D., Chabot J.A., Fojo A., Oberstein P.E., Hibshoosh H., Milsom J.W., Kulke M.H., Loda M., Chiosis G., Reidy-Lagunes D.L., Califano A.
Reply to 'H-STS, L-STS and KRJ-I are not authentic GEPNET cell lines'.
Nat. Genet. 51:1427-1428(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_L296
Chemistry resources PharmacoDB; HSTS_623_2019
Encyclopedic resources Wikidata; Q54871894
Gene expression databases GEO; GSM966943
Polymorphism and mutation databases Progenetix; CVCL_L296
Entry history
Entry creation06-May-2013
Last entry update10-Apr-2025
Version number18