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Cellosaurus H-STS (CVCL_L296)

[Text version]
Cell line name H-STS
Synonyms HSTS
Accession CVCL_L296
Resource Identification Initiative To cite this cell line use: H-STS (RRID:CVCL_L296)
Comments Problematic cell line: Misclassified. Originally thought to arise from a metastatic carcinoid of the terminal ileum but shown to be an EBV-transformed lymphoblastoid cell line (PubMed=29444910; PubMed=31548718). Although misidentified, it has been argued that transcriptional regulation of the cells enough resemble gastroenteropancreatic neuroendocrine tumors to be used in studies (PubMed=31548719).
Doubling time: ~3 days (PubMed=19528452).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Variations; SNP array analysis.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_L297 ! L-STS
CVCL_L298 ! P-STS
Sex of cell Male
Age at sampling 42Y
Category Transformed cell line
STR profile Source(s): PubMed=29444910

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81811
D7S82010,12
D13S3178,14
D16S53913
D21S1128,30
TH019,9.3
TPOX8
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=19528452
Roswitha Pfragner, Annemarie Behmel, Harald Hoger, Alfred Beham, Elisabeth Ingolic, Ingeborg Stelzer, Bernhard Svejda, Victor Aguiriano Moser, Anna Christina Obenauf, Veronika Siegl, Oskar Arthur Haas, Bruno Niederle;
Establishment and characterization of three novel cell lines -- P-STS, L-STS, H-STS -- derived from a human metastatic midgut carcinoid.
Anticancer Res. 29:1951-1961(2009)

PubMed=29444910; DOI=10.1530/ERC-17-0445; PMCID=PMC5827037
Tobias Hofving, Yvonne Arvidsson, Bilal Almobarak, Linda Inge, Roswitha Pfragner, Marta Persson, Goran Stenman, Erik Kristiansson, Viktor Johanson, Ola Nilsson;
The neuroendocrine phenotype, genomic profile and therapeutic sensitivity of GEPNET cell lines.
Endocr. Relat. Cancer 25:367-380(2018)

PubMed=31548718; DOI=10.1038/s41588-019-0490-z
Tobias Hofving, Joakim W. Karlsson, Ola Nilsson, Jonas A. Nilsson;
H-STS, L-STS and KRJ-I are not authentic GEPNET cell lines.
Nat. Genet. 51:1426-1427(2019)

PubMed=31548719; DOI=10.1038/s41588-019-0509-5; PMCID=PMC7256901
Mariano J. Alvarez, Peng-Rong Yan, Mary L. Alpaugh, Michaela Bowden, Ewa T. Sicinska, Chen-Sheng W. Zhou, Charles Karan, Ronald B. Realubit, Prabhjot Singh Mundi, Adina Grunn, Dirk Jager ...Show all 21 authors... , John A. Chabot, Antonio Fojo, Paul E. Oberstein, Hanina Hibshoosh, Jeffrey W. Milsom, Matthew Helmut Kulke, Massimo Loda, Gabriela Chiosis, Diane L. Reidy-Lagunes, Andrea Califano; Show fewer authors
Reply to 'H-STS, L-STS and KRJ-I are not authentic GEPNET cell lines'.
Nat. Genet. 51:1427-1428(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_L296
Chemistry resources PharmacoDB; HSTS_623_2019
Encyclopedic resources Wikidata; Q54871894
Gene expression databases GEO; GSM966943
Polymorphism and mutation databases Progenetix; CVCL_L296
Entry history
Entry creation06-May-2013
Last entry update10-Apr-2025
Version number18