ID   H-STS
AC   CVCL_L296
SY   HSTS
DR   cancercelllines; CVCL_L296
DR   GEO; GSM966943
DR   PharmacoDB; HSTS_623_2019
DR   Progenetix; CVCL_L296
DR   Wikidata; Q54871894
RX   PubMed=19528452;
RX   PubMed=29444910;
RX   PubMed=31548718;
RX   PubMed=31548719;
CC   Problematic cell line: Misclassified. Originally thought to arise from a metastatic carcinoid of the terminal ileum but shown to be an EBV-transformed lymphoblastoid cell line (PubMed=29444910; PubMed=31548718). Although misidentified, it has been argued that transcriptional regulation of the cells enough resemble gastroenteropancreatic neuroendocrine tumors to be used in studies (PubMed=31548719).
CC   Doubling time: ~3 days (PubMed=19528452).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
ST   Source(s): PubMed=29444910
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 8,14
ST   D16S539: 13
ST   D21S11: 28,30
ST   D5S818: 11
ST   D7S820: 10,12
ST   TH01: 9,9.3
ST   TPOX: 8
ST   vWA: 17,19
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_L297 ! L-STS
OI   CVCL_L298 ! P-STS
SX   Male
AG   42Y
CA   Transformed cell line
DT   Created: 06-05-13; Last updated: 10-04-25; Version: 18
//
RX   PubMed=29444910; DOI=10.1530/ERC-17-0445; PMCID=PMC5827037;
RA   Hofving, Tobias
RA   Arvidsson, Yvonne
RA   Almobarak, Bilal
RA   Inge, Linda
RA   Pfragner, Roswitha
RA   Persson, Marta
RA   Stenman, Goran
RA   Kristiansson, Erik
RA   Johanson, Viktor
RA   Nilsson, Ola
RT   "The neuroendocrine phenotype, genomic profile and therapeutic
RT   sensitivity of GEPNET cell lines.";
RL   Endocr. Relat. Cancer 25:367-380(2018).
//
RX   PubMed=31548719; DOI=10.1038/s41588-019-0509-5; PMCID=PMC7256901;
RA   Alvarez, Mariano J.
RA   Yan, Peng-Rong
RA   Alpaugh, Mary L.
RA   Bowden, Michaela
RA   Sicinska, Ewa T.
RA   Zhou, Chen-Sheng W.
RA   Karan, Charles
RA   Realubit, Ronald B.
RA   Mundi, Prabhjot Singh
RA   Grunn, Adina
RA   Jager, Dirk
RA   Chabot, John A.
RA   Fojo, Antonio
RA   Oberstein, Paul E.
RA   Hibshoosh, Hanina
RA   Milsom, Jeffrey W.
RA   Kulke, Matthew Helmut
RA   Loda, Massimo
RA   Chiosis, Gabriela
RA   Reidy-Lagunes, Diane L.
RA   Califano, Andrea
RT   "Reply to 'H-STS, L-STS and KRJ-I are not authentic GEPNET cell
RT   lines'.";
RL   Nat. Genet. 51:1427-1428(2019).
//
RX   PubMed=31548718; DOI=10.1038/s41588-019-0490-z;
RA   Hofving, Tobias
RA   Karlsson, Joakim W.
RA   Nilsson, Ola
RA   Nilsson, Jonas A.
RT   "H-STS, L-STS and KRJ-I are not authentic GEPNET cell lines.";
RL   Nat. Genet. 51:1426-1427(2019).
//
RX   PubMed=19528452;
RA   Pfragner, Roswitha
RA   Behmel, Annemarie
RA   Hoger, Harald
RA   Beham, Alfred
RA   Ingolic, Elisabeth
RA   Stelzer, Ingeborg
RA   Svejda, Bernhard
RA   Moser, Victor Aguiriano
RA   Obenauf, Anna Christina
RA   Siegl, Veronika
RA   Haas, Oskar Arthur
RA   Niederle, Bruno
RT   "Establishment and characterization of three novel cell lines -- P-STS,
RT   L-STS, H-STS -- derived from a human metastatic midgut carcinoid.";
RL   Anticancer Res. 29:1951-1961(2009).
//