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Cellosaurus HEI-286 F-GFP (CVCL_E9C0)

[Text version]
Cell line name HEI-286 F-GFP
Synonyms HEI-286-GFP
Accession CVCL_E9C0
Resource Identification Initiative To cite this cell line use: HEI-286 F-GFP (RRID:CVCL_E9C0)
Comments Characteristics: Expresses farnesylated GFP (PubMed=26999607).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Transcriptomics; Microarray.
Donor information: Established from an acoustic neuroma patient (CelloPub=CLPUB00805).
Derived from site: In situ; Peripheral nervous system, vestibular nerve; UBERON=UBERON_0003723.
Cell type: Schwann cell; CL=CL_0002573.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E9BY (HEI286)
Children:
CVCL_E9C1 (HEI-286 F-GFP JUN KO)
Sex of cell Male
Age at sampling 61Y
Category Transformed cell line
Publications

PubMed=26999607; DOI=10.1172/JCI82658; PMCID=PMC4811155
Sylvie Deborde, Tatiana Omelchenko, Anna Lyubchik, Yi Zhou, Shi-Zhi He, William Francis McNamara, Natalya Chernichenko, Sei-Young Lee, Fernando Barajas, Chun-Hao Chen, Richard L. Bakst ...Show all 15 authors... , Efsevia Vakiani, Shuang-Ba He, Alan Hall, Richard J. Wong; Show fewer authors
Schwann cells induce cancer cell dispersion and invasion.
J. Clin. Invest. 126:1538-1554(2016)

PubMed=35881881; DOI=10.1158/2159-8290.CD-21-1690; PMCID=PMC9533012
Sylvie Deborde, Laxmi Gusain, Ann Powers, Andrea R. Marcadis, Ya-Song Yu, Chun-Hao Chen, Anna Frants, Elizabeth Kao, Laura H. Tang, Efsevia Vakiani, Masataka Amisaki ...Show all 17 authors... , Vinod P. Balachandran, Annalisa Calo, Tatiana Omelchenko, Kristjan R. Jessen, Boris A. Reva, Richard J. Wong; Show fewer authors
Reprogrammed Schwann cells organize into dynamic tracks that promote pancreatic cancer invasion.
Cancer Discov. 12:2454-2473(2022)

Entry history
Entry creation14-Aug-2025
Last entry update14-Aug-2025
Version number1