Cellosaurus cell line HEI286 (CVCL

Cellosaurus HEI286 (CVCL_E9BY)

[Text version]

Cell line name

HEI286

Synonyms

HEI-286; HEI 286; House Ear Institute 286

Accession

CVCL_E9BY

Resource Identification Initiative

To cite this cell line use: HEI286 (RRID:CVCL_E9BY)

Comments

Doubling time: 38 hours (CelloPub=CLPUB00805).
Karyotypic information: Hypo-triploid male (XO) with most chromosome counts in the 60-68 range (CelloPub=CLPUB00805).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Transcriptomics; Microarray.
Donor information: Established from an acoustic neuroma patient (CelloPub=CLPUB00805).
Miscellaneous: STR profile from personal communication of Stupakov, Pavel.
Derived from site: In situ; Peripheral nervous system, vestibular nerve; UBERON=UBERON_0003723.
Cell type: Schwann cell; CL=CL_0002573.

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Children:

CVCL_E9C0 (HEI-286 F-GFP)

Sex of cell

Male

Age at sampling

61Y

Category

Transformed cell line

STR profile

Source(s): Direct_author_submission

Markers:

Amelogenin	X
CSF1PO	11,12
D3S1358	15,18
D5S818	11,12
D7S820	9,10
D8S1179	10,13
D13S317	14
D16S539	14
D18S51	17
D21S11	31,31.2
FGA	21,22
Penta D	12,13
Penta E	16
TH01	7,9.3
TPOX	8,11
vWA	15,18

Publications

CLPUB00805
Ali Andalibi;
Establish an in vitro model for the study of NF2 gene function and gene therapy.
(In misc. document) Report for award DAMD17-99-1-9491. Defense Technical Information Center document ADA431978; pp.1-52; DTIC; Fort Belvoir; USA (2004)

PubMed=20178741; DOI=10.1016/j.cell.2010.01.029; PMCID=PMC2828953
Wei Li, Li-Ru You, Jonathan E. Cooper, Gaia Schiavon, Angela Pepe-Caprio, Lu Zhou, Ryohei Ishii, Marco Giovannini, Clemens Oliver Hanemann, Stephen B. Long, Hediye Erdjument-Bromage ...Show all 14 authors... , Peng-Bo Zhou, Paul Tempst, Filippo G. Giancotti; Show fewer authors
Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.
Cell 140:477-490(2010)

PubMed=26999607; DOI=10.1172/JCI82658; PMCID=PMC4811155
Sylvie Deborde, Tatiana Omelchenko, Anna Lyubchik, Yi Zhou, Shi-Zhi He, William Francis McNamara, Natalya Chernichenko, Sei-Young Lee, Fernando Barajas, Chun-Hao Chen, Richard L. Bakst ...Show all 15 authors... , Efsevia Vakiani, Shuang-Ba He, Alan Hall, Richard J. Wong; Show fewer authors
Schwann cells induce cancer cell dispersion and invasion.
J. Clin. Invest. 126:1538-1554(2016)

PubMed=35881881; DOI=10.1158/2159-8290.CD-21-1690; PMCID=PMC9533012
Sylvie Deborde, Laxmi Gusain, Ann Powers, Andrea R. Marcadis, Ya-Song Yu, Chun-Hao Chen, Anna Frants, Elizabeth Kao, Laura H. Tang, Efsevia Vakiani, Masataka Amisaki ...Show all 17 authors... , Vinod P. Balachandran, Annalisa Calo, Tatiana Omelchenko, Kristjan R. Jessen, Boris A. Reva, Richard J. Wong; Show fewer authors
Reprogrammed Schwann cells organize into dynamic tracks that promote pancreatic cancer invasion.
Cancer Discov. 12:2454-2473(2022)

Cross-references

Gene expression databases

GEO; GSM5481587
GEO; GSM5481588
GEO; GSM5481589
GEO; GSM5481590

Entry history

Entry creation

14-Aug-2025

Last entry update

14-Aug-2025

Version number