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Cellosaurus HEI-286 F-GFP JUN KO (CVCL_E9C1)

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Cell line name HEI-286 F-GFP JUN KO
Synonyms c-Jun KO HEI-GFP
Accession CVCL_E9C1
Resource Identification Initiative To cite this cell line use: HEI-286 F-GFP JUN KO (RRID:CVCL_E9C1)
Comments Characteristics: Expresses farnesylated GFP (from parent cell line).
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:6204; JUN.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Transcriptomics; Microarray.
Donor information: Established from an acoustic neuroma patient (CelloPub=CLPUB00805).
Derived from site: In situ; Peripheral nervous system, vestibular nerve; UBERON=UBERON_0003723.
Cell type: Schwann cell; CL=CL_0002573.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E9C0 (HEI-286 F-GFP)
Sex of cell Male
Age at sampling 61Y
Category Transformed cell line
Publications

PubMed=35881881; DOI=10.1158/2159-8290.CD-21-1690; PMCID=PMC9533012
Sylvie Deborde, Laxmi Gusain, Ann Powers, Andrea R. Marcadis, Ya-Song Yu, Chun-Hao Chen, Anna Frants, Elizabeth Kao, Laura H. Tang, Efsevia Vakiani, Masataka Amisaki ...Show all 17 authors... , Vinod P. Balachandran, Annalisa Calo, Tatiana Omelchenko, Kristjan R. Jessen, Boris A. Reva, Richard J. Wong; Show fewer authors
Reprogrammed Schwann cells organize into dynamic tracks that promote pancreatic cancer invasion.
Cancer Discov. 12:2454-2473(2022)

Entry history
Entry creation14-Aug-2025
Last entry update14-Aug-2025
Version number1