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Cellosaurus K1735-C4 (CVCL_E7ZF)

[Text version]
Cell line name K1735-C4
Synonyms K-1735 C4; K-1735 clone 4; K1735C4; C4; C4.P
Accession CVCL_E7ZF
Resource Identification Initiative To cite this cell line use: K1735-C4 (RRID:CVCL_E7ZF)
Comments Characteristics: Highly metastatic. Produces melanotic lung metastases in syngeneic mice.
Transformant: NCIt; C17231; Ultraviolet radiation.
Sequence variations
  • Mutation; MGI; MGI:97376; Nras; Simple; p.Gly13Asp (c.38G>A); Zygosity=Unspecified (from parent cell line).
Disease Mouse melanoma (NCIt: C21790)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C3H/HeN.
Hierarchy Parent: CVCL_F828 (K1735)
Children:
CVCL_E7ZH (K1735-C4.Neo.3)CVCL_E7ZI (K1735-C4.L8.5)CVCL_E7ZJ (K1735-C4.S2-3)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Web pages Provider; MD Anderson CCAC; -; https://www.mdanderson.org/content/dam/mdanderson/documents/core-facilities/Cytogenetics-and-Cell-Authentication-Core/Cell%20Line%20List%203-23-2022.pdf
Publications

PubMed=6944560; DOI=10.1093/jnci/67.4.947
Isaiah Joshua Fidler, Eilene Gruys, Maria A. Cifone, Zoa Barnes, Corazon D. Bucana;
Demonstration of multiple phenotypic diversity in a murine melanoma of recent origin.
J. Natl. Cancer Inst. 67:947-956(1981)

PubMed=7535333; DOI=10.1084/jem.181.4.1333; PMCID=PMC2191958
Ke-Ping Xie, Su-Yun Huang, Zhong-Yun Dong, Shin-Hun Juang, Mordechai Gutman, Qiao-Wen Xie, Carl F. Nathan, Isaiah Joshua Fidler;
Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells.
J. Exp. Med. 181:1333-1343(1995)

Entry history
Entry creation10-Apr-2025
Last entry update14-Aug-2025
Version number2