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Cellosaurus ARCaPE (CVCL_E7VJ)

[Text version]
Cell line name ARCaPE
Synonyms ARCaP(E); ARCaP clone IF11; ARCaP Epithelial
Accession CVCL_E7VJ
Resource Identification Initiative To cite this cell line use: ARCaPE (RRID:CVCL_E7VJ)
Comments Population: Caucasian.
Characteristics: Exhibits a cobblestone shaped morphology. Undergoes epithelial to mesenchymal transition (EMT) through cellular interaction with host bone and adrenal gland (PubMed=16902972).
Omics: Transcriptomics; miRNA profiling; RNAseq.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4830 (ARCaP)
Children:
CVCL_E7VL (ARCaPE-shEPLIN)
Sex of cell Male
Age at sampling 83Y
Category Cancer cell line
Publications

PubMed=16902972; DOI=10.1002/pros.20488
Xu J.-C., Wang R.-X., Xie Z.-H., Odero-Marah V., Pathak S., Multani A.S., Chung L.W.K., Zhau H.-Y.E.
Prostate cancer metastasis: role of the host microenvironment in promoting epithelial to mesenchymal transition and increased bone and adrenal gland metastasis.
Prostate 66:1664-1673(2006)

PubMed=21625216; DOI=10.1038/onc.2011.199; PMCID=PMC3165108
Zhang S.-M., Wang X., Osunkoya A.O., Iqbal S.A., Wang Y., Chen Z., Muller S., Chen Z.-J., Josson S., Coleman I.M., Nelson P.S., Wang Y.-Q.A., Wang R.-X., Shin D.M., Marshall F.F., Kucuk O., Chung L.W.K., Zhau H.-Y.E., Wu D.-Q.
EPLIN downregulation promotes epithelial-mesenchymal transition in prostate cancer cells and correlates with clinical lymph node metastasis.
Oncogene 30:4941-4952(2011)

PubMed=32231998; DOI=10.3389/fonc.2020.00292; PMCID=PMC7082744
Rao S.R., Howarth A., Kratschmer P., Snaith A.E., Yapp C., Ebner D., Hamdy F.C., Edwards C.M.
Transcriptomic and functional screens reveal microRNAs that modulate prostate cancer metastasis.
Front. Oncol. 10:292.1-292.15(2020)

Cross-references
Gene expression databases GEO; GSM4306193
GEO; GSM4306194
GEO; GSM4306195
Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1