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Cellosaurus ARCaPE (CVCL_E7VJ)

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Cell line name ARCaPE
Synonyms ARCaP(E); ARCaP clone IF11; ARCaP Epithelial
Accession CVCL_E7VJ
Resource Identification Initiative To cite this cell line use: ARCaPE (RRID:CVCL_E7VJ)
Comments Population: Caucasian.
Characteristics: Exhibits a cobblestone shaped morphology. Undergoes epithelial to mesenchymal transition (EMT) through cellular interaction with host bone and adrenal gland (PubMed=16902972).
Omics: Transcriptomics; miRNA profiling; RNAseq.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4830 (ARCaP)
Children:
CVCL_E7VL (ARCaPE-shEPLIN)
Sex of cell Male
Age at sampling 83Y
Category Cancer cell line
Publications

PubMed=16902972; DOI=10.1002/pros.20488
Jian-Chun Xu, Ruo-Xiang Wang, Zhi-Hui Xie, Valerie Odero-Marah, Sen Pathak, Asha S. Multani, Leland W.K. Chung, Hai-Yen E. Zhau;
Prostate cancer metastasis: role of the host microenvironment in promoting epithelial to mesenchymal transition and increased bone and adrenal gland metastasis.
Prostate 66:1664-1673(2006)

PubMed=21625216; DOI=10.1038/onc.2011.199; PMCID=PMC3165108
Shu-Min Zhang, Xu Wang, Adeboye O. Osunkoya, Shareen A. Iqbal, Yan-Ru Wang, Zhuo Chen, Susan Muller, Zheng-Jia Chen, Sajni Josson, Ilsa M. Coleman, Peter S. Nelson ...Show all 19 authors... , Yong-Qiang Andrew Wang, Ruo-Xiang Wang, Dong Moon Shin, Fray Francis Marshall, Omer Kucuk, Leland W.K. Chung, Hai-Yen E. Zhau, Da-Qing Wu; Show fewer authors
EPLIN downregulation promotes epithelial-mesenchymal transition in prostate cancer cells and correlates with clinical lymph node metastasis.
Oncogene 30:4941-4952(2011)

PubMed=32231998; DOI=10.3389/fonc.2020.00292; PMCID=PMC7082744
Srinivasa Rao Rao, Alison Howarth, Patrick Kratschmer, Ann E. Snaith, Clarence Yapp, Daniel Ebner, Freddie Charles Hamdy, Claire M. Edwards;
Transcriptomic and functional screens reveal microRNAs that modulate prostate cancer metastasis.
Front. Oncol. 10:292.1-292.15(2020)

Cross-references
Gene expression databases GEO; GSM4306193
GEO; GSM4306194
GEO; GSM4306195
Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1