ID   ARCaPE
AC   CVCL_E7VJ
SY   ARCaP(E); ARCaP clone IF11; ARCaP Epithelial
DR   GEO; GSM4306193
DR   GEO; GSM4306194
DR   GEO; GSM4306195
RX   PubMed=16902972;
RX   PubMed=21625216;
RX   PubMed=32231998;
CC   Population: Caucasian.
CC   Characteristics: Exhibits a cobblestone shaped morphology. Undergoes epithelial to mesenchymal transition (EMT) through cellular interaction with host bone and adrenal gland (PubMed=16902972).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Unspecified (from parent cell line).
CC   Omics: Transcriptomics; miRNA profiling; RNAseq.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4830 ! ARCaP
SX   Male
AG   83Y
CA   Cancer cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
//
RX   PubMed=16902972; DOI=10.1002/pros.20488;
RA   Xu J.-C., Wang R.-X., Xie Z.-H., Odero-Marah V., Pathak S., Multani A.S.,
RA   Chung L.W.K., Zhau H.-Y.E.;
RT   "Prostate cancer metastasis: role of the host microenvironment in
RT   promoting epithelial to mesenchymal transition and increased bone and
RT   adrenal gland metastasis.";
RL   Prostate 66:1664-1673(2006).
//
RX   PubMed=21625216; DOI=10.1038/onc.2011.199; PMCID=PMC3165108;
RA   Zhang S.-M., Wang X., Osunkoya A.O., Iqbal S.A., Wang Y., Chen Z.,
RA   Muller S., Chen Z.-J., Josson S., Coleman I.M., Nelson P.S.,
RA   Wang Y.-Q.A., Wang R.-X., Shin D.M., Marshall F.F., Kucuk O.,
RA   Chung L.W.K., Zhau H.-Y.E., Wu D.-Q.;
RT   "EPLIN downregulation promotes epithelial-mesenchymal transition in
RT   prostate cancer cells and correlates with clinical lymph node
RT   metastasis.";
RL   Oncogene 30:4941-4952(2011).
//
RX   PubMed=32231998; DOI=10.3389/fonc.2020.00292; PMCID=PMC7082744;
RA   Rao S.R., Howarth A., Kratschmer P., Snaith A.E., Yapp C., Ebner D.,
RA   Hamdy F.C., Edwards C.M.;
RT   "Transcriptomic and functional screens reveal microRNAs that modulate
RT   prostate cancer metastasis.";
RL   Front. Oncol. 10:292.1-292.15(2020).
//