Cellosaurus cell line ARCaPE-shEPLIN (CVCL

Cellosaurus ARCaPE-shEPLIN (CVCL_E7VL)

Entry history
Cell line name	ARCaPE-shEPLIN
Synonyms	ARCaPE-shRNA clone #102)
Accession	CVCL_E7VL
Resource Identification Initiative	To cite this cell line use: ARCaPE-shEPLIN (RRID:CVCL_E7VL)
Comments	Population: Caucasian. Knockout cell: Method=shRNA knockdown; HGNC; HGNC:24636; LIMA1. Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Unspecified (from parent cell line).
Disease	Prostate carcinoma (NCIt: C4863)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_E7VJ (ARCaPE)
Sex of cell	Male
Age at sampling	83Y
Category	Cancer cell line
Web pages	Provider; Emory OTT; RT006; https://emoryott.technologypublisher.com/techcase/RT006
Publications	PubMed=21625216; DOI=10.1038/onc.2011.199; PMCID=PMC3165108 Shu-Min Zhang, Xu Wang, Adeboye O. Osunkoya, Shareen A. Iqbal, Yan-Ru Wang, Zhuo Chen, Susan Muller, Zheng-Jia Chen, Sajni Josson, Ilsa M. Coleman, Peter S. Nelson ...Show all 19 authors... , Yong-Qiang Andrew Wang, Ruo-Xiang Wang, Dong Moon Shin, Fray Francis Marshall, Omer Kucuk, Leland W.K. Chung, Hai-Yen E. Zhau, Da-Qing Wu; Show fewer authors EPLIN downregulation promotes epithelial-mesenchymal transition in prostate cancer cells and correlates with clinical lymph node metastasis. Oncogene 30:4941-4952(2011)
Entry creation	10-Apr-2025
Last entry update	14-Aug-2025
Version number	2