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Cellosaurus HepAD43 (CVCL_DE22)

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Cell line name HepAD43
Synonyms Hep AD43
Accession CVCL_DE22
Resource Identification Initiative To cite this cell line use: HepAD43 (RRID:CVCL_DE22)
Comments Population: Caucasian.
Biotechnology: Control cell line for the bioassay based on HepAD38 (Cellosaurus=CVCL_M177) or HepAD79 (Cellosaurus=CVCL_DE23).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00722; Escherichia coli beta-galactosidase (lacZ).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=21331898; DOI=10.1385/1-59259-245-7:43
Robert W. King, Stephanie K. Ladner;
Hep AD38 assay: a high-throughput, cell-based screen for the evaluation of compounds against hepatitis B virus.
Methods Mol. Med. 24:43-50(2000)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DE22
Encyclopedic resources Wikidata; Q54882830
Entry history
Entry creation13-Jul-2016
Last entry update19-Dec-2024
Version number18