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Cellosaurus HepAD79 (CVCL_DE23)

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Cell line name HepAD79
Synonyms Hep AD79; HepG2-AD79; AD-79; AD79
Accession CVCL_DE23
Resource Identification Initiative To cite this cell line use: HepAD79 (RRID:CVCL_DE23)
Comments Population: Caucasian.
Virology: Inducibly expresses a lamivudine-resistant hepatitis B virus (HBV) genome under the control of a tet operator/CMV promoter. Upon removal of tetracycline the cell line produces viral RNA and secrete virus-like particles into the supernatant (PubMed=9875378).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=9875378
Stephanie K. Ladner, Timothy J. Miller, Michael J. Otto, Robert W. King;
The hepatitis B virus M539V polymerase variation responsible for 3TC resistance also confers cross-resistance to other nucleoside analogues.
Antivir. Chem. Chemother. 9:65-72(1998)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DE23
Encyclopedic resources Wikidata; Q54882831
Entry history
Entry creation13-Jul-2016
Last entry update27-Nov-2025
Version number17