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Cellosaurus CHO-AUXB1 (CVCL_D264)

[Text version]
Cell line name CHO-AUXB1
Synonyms CHO AUXB1; AuxB1; AUXB1; AUX B1; Aux-B1; AuX B1; Gat-(CHO)
Accession CVCL_D264
Resource Identification Initiative To cite this cell line use: CHO-AUXB1 (RRID:CVCL_D264)
Comments Characteristics: Auxotrophic for glycine, adenosine, and thymidine (GAT-) (PubMed=4547236).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_7183 (CHO-S)
Children:
CVCL_C7GJ (AuxB1 DeltaP-gp B1)CVCL_C7GK (AuxB1 DeltaP-gp B2)CVCL_D265 (CHO-CHRC4)
CVCL_D266 (CHO-CHRC5)CVCL_4702 (CHOP)CVCL_M726 (DNRR5)
CVCL_M727 (DNRR51)CVCL_C8BU (tsAUXB1)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=4472030; DOI=10.1016/0092-8674(74)90092-0
McBurney M.W., Whitmore G.F.
Characterization of a Chinese hamster cell with a temperature-sensitive mutation in folate metabolism.
Cell 2:183-188(1974)

PubMed=4547236; DOI=10.1016/0092-8674(74)90091-9
McBurney M.W., Whitmore G.F.
Isolation and biochemical characterization of folate deficient mutants of Chinese hamster cells.
Cell 2:173-182(1974)

PubMed=688393; DOI=10.1016/0092-8674(78)90354-9
Gupta R.S., Chan D.Y.-H., Siminovitch L.
Evidence for functional hemizygosity at the Emtr locus in CHO cells through segregation analysis.
Cell 14:1007-1013(1978)

PubMed=583488; DOI=10.1016/0003-9861(79)90215-7
Taylor R.T., Hanna M.L.
Folate-dependent enzymes in cultured Chinese hamster ovary cells: evidence for mutant forms of folylpolyglutamate synthetase.
Arch. Biochem. Biophys. 197:36-43(1979)

PubMed=3839900; DOI=10.1016/0027-5107(85)90082-X
Taylor R.T., Wu R., Hanna M.L.
Induced reversion of a Chinese hamster ovary triple auxotroph Validation of the system with several mutagens.
Mutat. Res. 151:293-308(1985)

PubMed=3365701
Biedler J.L., Chang T.-D., Scotto K.W., Melera P.W., Spengler B.A.
Chromosomal organization of amplified genes in multidrug-resistant Chinese hamster cells.
Cancer Res. 48:3179-3187(1988)

PubMed=35381425; DOI=10.1016/j.bbrc.2022.03.148
Limniatis G., Georges E.
Knockout of P-glycoprotein abolish the collateral sensitivity of CHO(R)C5 multidrug resistant cells.
Biochem. Biophys. Res. Commun. 608:23-29(2022)

Cross-references
Cell line databases/resources TOKU-E; 4114
Encyclopedic resources Wikidata; Q54812642
Entry history
Entry creation22-Oct-2012
Last entry update30-Jan-2024
Version number11