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Cellosaurus CHO-AUXB1 (CVCL_D264)

[Text version]
Cell line name CHO-AUXB1
Synonyms CHO AUXB1; AuxB1; AUXB1; AUX B1; Aux-B1; AuX B1; Gat-(CHO); gat-CHO
Accession CVCL_D264
Resource Identification Initiative To cite this cell line use: CHO-AUXB1 (RRID:CVCL_D264)
Comments Characteristics: Auxotrophic for glycine, adenosine, and thymidine (GAT-) (PubMed=4547236).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_7183 (CHO-S)
Children:
CVCL_C7GJ (AuxB1 DeltaP-gp B1)CVCL_C7GK (AuxB1 DeltaP-gp B2)CVCL_F0DD (CHO Toyr-15)
CVCL_F0DE (CHO Toyr-16)CVCL_D5AR (CHO-AUXB1 HuR-12)CVCL_D265 (CHO-CHRC4)
CVCL_D266 (CHO-CHRC5)CVCL_4702 (CHOP)CVCL_M726 (DNRR5)
CVCL_M727 (DNRR51)CVCL_C8BU (tsAUXB1)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=4472030; DOI=10.1016/0092-8674(74)90092-0
Michael W. McBurney, Gordon Francis Whitmore;
Characterization of a Chinese hamster cell with a temperature-sensitive mutation in folate metabolism.
Cell 2:183-188(1974)

PubMed=4547236; DOI=10.1016/0092-8674(74)90091-9
Michael W. McBurney, Gordon Francis Whitmore;
Isolation and biochemical characterization of folate deficient mutants of Chinese hamster cells.
Cell 2:173-182(1974)

PubMed=688393; DOI=10.1016/0092-8674(78)90354-9
Radhey Shyam Gupta, David Y.-H. Chan, Louis Siminovitch;
Evidence for functional hemizygosity at the Emtr locus in CHO cells through segregation analysis.
Cell 14:1007-1013(1978)

PubMed=583488; DOI=10.1016/0003-9861(79)90215-7
Robert T. Taylor, M. Leslie Hanna;
Folate-dependent enzymes in cultured Chinese hamster ovary cells: evidence for mutant forms of folylpolyglutamate synthetase.
Arch. Biochem. Biophys. 197:36-43(1979)

PubMed=3839900; DOI=10.1016/0027-5107(85)90082-X
Robert T. Taylor, Rebekah Wu, M. Leslie Hanna;
Induced reversion of a Chinese hamster ovary triple auxotroph Validation of the system with several mutagens.
Mutat. Res. 151:293-308(1985)

PubMed=3365701
June Lee Biedler, Tien-Ding Chang, Kathleen W. Scotto, Peter W. Melera, Barbara A. Spengler;
Chromosomal organization of amplified genes in multidrug-resistant Chinese hamster cells.
Cancer Res. 48:3179-3187(1988)

PubMed=35381425; DOI=10.1016/j.bbrc.2022.03.148
Georgia Limniatis, Elias Georges;
Knockout of P-glycoprotein abolish the collateral sensitivity of CHO(R)C5 multidrug resistant cells.
Biochem. Biophys. Res. Commun. 608:23-29(2022)

Cross-references
Cell line databases/resources TOKU-E; 4114
Encyclopedic resources Wikidata; Q54812642
Entry history
Entry creation22-Oct-2012
Last entry update02-May-2024
Version number12