ID   CHO-AUXB1
AC   CVCL_D264
SY   CHO AUXB1; AuxB1; AUXB1; AUX B1; Aux-B1; AuX B1; Gat-(CHO); gat-CHO
DR   TOKU-E; 4114
DR   Wikidata; Q54812642
RX   PubMed=583488;
RX   PubMed=688393;
RX   PubMed=3365701;
RX   PubMed=3839900;
RX   PubMed=4472030;
RX   PubMed=4547236;
RX   PubMed=35381425;
CC   Characteristics: Auxotrophic for glycine, adenosine, and thymidine (GAT-) (PubMed=4547236).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_7183 ! CHO-S
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 22-10-12; Last updated: 02-05-24; Version: 12
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RX   PubMed=583488; DOI=10.1016/0003-9861(79)90215-7;
RA   Taylor R.T., Hanna M.L.;
RT   "Folate-dependent enzymes in cultured Chinese hamster ovary cells:
RT   evidence for mutant forms of folylpolyglutamate synthetase.";
RL   Arch. Biochem. Biophys. 197:36-43(1979).
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RX   PubMed=688393; DOI=10.1016/0092-8674(78)90354-9;
RA   Gupta R.S., Chan D.Y.-H., Siminovitch L.;
RT   "Evidence for functional hemizygosity at the Emtr locus in CHO cells
RT   through segregation analysis.";
RL   Cell 14:1007-1013(1978).
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RX   PubMed=3365701;
RA   Biedler J.L., Chang T.-D., Scotto K.W., Melera P.W., Spengler B.A.;
RT   "Chromosomal organization of amplified genes in multidrug-resistant
RT   Chinese hamster cells.";
RL   Cancer Res. 48:3179-3187(1988).
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RX   PubMed=3839900; DOI=10.1016/0027-5107(85)90082-X;
RA   Taylor R.T., Wu R., Hanna M.L.;
RT   "Induced reversion of a Chinese hamster ovary triple auxotroph.
RT   Validation of the system with several mutagens.";
RL   Mutat. Res. 151:293-308(1985).
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RX   PubMed=4472030; DOI=10.1016/0092-8674(74)90092-0;
RA   McBurney M.W., Whitmore G.F.;
RT   "Characterization of a Chinese hamster cell with a
RT   temperature-sensitive mutation in folate metabolism.";
RL   Cell 2:183-188(1974).
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RX   PubMed=4547236; DOI=10.1016/0092-8674(74)90091-9;
RA   McBurney M.W., Whitmore G.F.;
RT   "Isolation and biochemical characterization of folate deficient
RT   mutants of Chinese hamster cells.";
RL   Cell 2:173-182(1974).
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RX   PubMed=35381425; DOI=10.1016/j.bbrc.2022.03.148;
RA   Limniatis G., Georges E.;
RT   "Knockout of P-glycoprotein abolish the collateral sensitivity of
RT   CHO(R)C5 multidrug resistant cells.";
RL   Biochem. Biophys. Res. Commun. 608:23-29(2022).
//