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Cellosaurus CHO-CHRC5 (CVCL_D266)

[Text version]
Cell line name CHO-CHRC5
Synonyms CHO/CHRC5; CHO CHRC5; CHRC/5; CHRC5; CHrC5; CHORC5
Accession CVCL_D266
Resource Identification Initiative To cite this cell line use: CHO-CHRC5 (RRID:CVCL_D266)
Comments Selected for resistance to: ChEBI; CHEBI_23359; Colchicine.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_D264 (CHO-AUXB1)
Children:
CVCL_4703 (CHO-CHRB30)CVCL_C7GL (CHORC5 DeltaP-gp A1)CVCL_C7GM (CHORC5 DeltaP-gp A2)
CVCL_C7GN (CHORC5 DeltaP-gp A3)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=4855907; DOI=10.1002/jcp.1040830114
Victor Ling, Lawrence H. Thompson;
Reduced permeability in CHO cells as a mechanism of resistance to colchicine.
J. Cell. Physiol. 83:103-116(1974)

PubMed=2412130; DOI=10.1038/316820a0
Norbert Kartner, Deanna Evernden-Porelle, Grace Bradley, Victor Ling;
Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies.
Nature 316:820-823(1985)

PubMed=3567908
Ans P.M. Jongsma, Barbara A. Spengler, Alexander M. van der Bliek, Piet Borst, June Lee Biedler;
Chromosomal localization of three genes coamplified in the multidrug-resistant CHRC5 Chinese hamster ovary cell line.
Cancer Res. 47:2875-2878(1987)

PubMed=2458323; DOI=10.1002/ijc.2910420314
Riekeld J. Scheper, Jeff W.M. Bulte, Joost G.P. Brakkee, Jasper J. Quak, C. Ellen van der Schoot, Alfons J.M. Balm, Chris J.L.M. Meijer, Henk J. Broxterman, Catharina M. Kuiper, Jan Lankelma, Herbert Michael Pinedo;
Monoclonal antibody JSB-1 detects a highly conserved epitope on the P-glycoprotein associated with multi-drug-resistance.
Int. J. Cancer 42:389-394(1988)

PubMed=3365701
June Lee Biedler, Tien-Ding Chang, Kathleen W. Scotto, Peter W. Melera, Barbara A. Spengler;
Chromosomal organization of amplified genes in multidrug-resistant Chinese hamster cells.
Cancer Res. 48:3179-3187(1988)

PubMed=2158805; DOI=10.1038/bjc.1990.127; PMCID=PMC1971365
Daniel Osvaldo Boscoboinik, Radhey Shyam Gupta, Richard M. Epand;
Investigation of the relationship between altered intracellular pH and multidrug resistance in mammalian cells.
Br. J. Cancer 61:568-572(1990)

PubMed=35381425; DOI=10.1016/j.bbrc.2022.03.148
Georgia Limniatis, Elias Georges;
Knockout of P-glycoprotein abolish the collateral sensitivity of CHO(R)C5 multidrug resistant cells.
Biochem. Biophys. Res. Commun. 608:23-29(2022)

Cross-references
Chemistry resources ChEMBL-Cells; CHEMBL3307930
ChEMBL-Targets; CHEMBL614457
PubChem_Cell_line; CVCL_D266
Encyclopedic resources Wikidata; Q54812654
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number15