ID   CHO-CHRC5
AC   CVCL_D266
SY   CHO/CHRC5; CHO CHRC5; CHRC/5; CHRC5; CHrC5; CHORC5
DR   ChEMBL-Cells; CHEMBL3307930
DR   ChEMBL-Targets; CHEMBL614457
DR   PubChem_Cell_line; CVCL_D266
DR   Wikidata; Q54812654
RX   PubMed=2158805;
RX   PubMed=2412130;
RX   PubMed=2458323;
RX   PubMed=3365701;
RX   PubMed=3567908;
RX   PubMed=4855907;
RX   PubMed=35381425;
CC   Selected for resistance to: ChEBI; CHEBI:23359; Colchicine.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_D264 ! CHO-AUXB1
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 22-10-12; Last updated: 30-01-24; Version: 14
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RX   PubMed=2158805; DOI=10.1038/bjc.1990.127;
RA   Boscoboinik D., Gupta R.S., Epand R.M.;
RT   "Investigation of the relationship between altered intracellular pH
RT   and multidrug resistance in mammalian cells.";
RL   Br. J. Cancer 61:568-572(1990).
//
RX   PubMed=2412130; DOI=10.1038/316820a0;
RA   Kartner N., Evernden-Porelle D., Bradley G., Ling V.;
RT   "Detection of P-glycoprotein in multidrug-resistant cell lines by
RT   monoclonal antibodies.";
RL   Nature 316:820-823(1985).
//
RX   PubMed=2458323; DOI=10.1002/ijc.2910420314;
RA   Scheper R.J., Bulte J.W.M., Brakkee J.G.P., Quak J.J.,
RA   van der Schoot C.E., Balm A.J.M., Meijer C.J.L.M., Broxterman H.J.,
RA   Kuiper C.M., Lankelma J., Pinedo H.M.;
RT   "Monoclonal antibody JSB-1 detects a highly conserved epitope on the
RT   P-glycoprotein associated with multi-drug-resistance.";
RL   Int. J. Cancer 42:389-394(1988).
//
RX   PubMed=3365701;
RA   Biedler J.L., Chang T.-D., Scotto K.W., Melera P.W., Spengler B.A.;
RT   "Chromosomal organization of amplified genes in multidrug-resistant
RT   Chinese hamster cells.";
RL   Cancer Res. 48:3179-3187(1988).
//
RX   PubMed=3567908;
RA   Jongsma A.P.M., Spengler B.A., van der Bliek A.M., Borst P.,
RA   Biedler J.L.;
RT   "Chromosomal localization of three genes coamplified in the
RT   multidrug-resistant CHRC5 Chinese hamster ovary cell line.";
RL   Cancer Res. 47:2875-2878(1987).
//
RX   PubMed=4855907; DOI=10.1002/jcp.1040830114;
RA   Ling V., Thompson L.H.;
RT   "Reduced permeability in CHO cells as a mechanism of resistance to
RT   colchicine.";
RL   J. Cell. Physiol. 83:103-116(1974).
//
RX   PubMed=35381425; DOI=10.1016/j.bbrc.2022.03.148;
RA   Limniatis G., Georges E.;
RT   "Knockout of P-glycoprotein abolish the collateral sensitivity of
RT   CHO(R)C5 multidrug resistant cells.";
RL   Biochem. Biophys. Res. Commun. 608:23-29(2022).
//