Cellosaurus MSOD (CVCL_C6VW)
Cell line name | MSOD | ||||||||||||||||||||||||||||||||
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Synonyms | M-SOD; Mesenchymal Sword of Damocles; hTERT-iDS; 196hT-iDS clone 20 | ||||||||||||||||||||||||||||||||
Accession | CVCL_C6VW | ||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: MSOD (RRID:CVCL_C6VW) | ||||||||||||||||||||||||||||||||
Comments | Group: Patented cell line. Characteristics: Capable to efficiently differentiate toward the osteogenic lineage (PubMed=24561906). Characteristics: Transduced with a lentiviral vector containing hTERT and eGFP respectively under the control of the CMV and EF1a promoters and a retro-vector containing iCas9-2A-CD19t under the control of a CMV promoter (PubMed=24561906). Characteristics: The suicide system of this cell line can be activated by addition of an homodimerizer that activates the apoptosis pathway through the dimerization of iCas9 (PubMed=24561906). Transfected with: HGNC; 1633; CD19 (with p.Lys324_Arg556del = CD19t). Transfected with: HGNC; 11730; TERT. Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP). Transfected with: UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9. Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371. Cell type: Mesenchymal stem cell of bone marrow; CL=CL_0002540. | ||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | ||||||||||||||||||||||||||||||||
Hierarchy | Parent: CVCL_C6VV (196hT) Children:
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Sex of cell | Female | ||||||||||||||||||||||||||||||||
Age at sampling | 51Y | ||||||||||||||||||||||||||||||||
Category | Telomerase immortalized cell line | ||||||||||||||||||||||||||||||||
STR profile | Source(s): PubMed=24561906 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||
Publications | Patent=WO2013186264A1 PubMed=24561906; DOI=10.1016/j.scr.2013.12.006 PubMed=34486186; DOI=10.1002/adma.202103737 | ||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||
Encyclopedic resources | Wikidata; Q117704716 | ||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||
Entry creation | 21-Mar-2023 | ||||||||||||||||||||||||||||||||
Last entry update | 29-Jun-2023 | ||||||||||||||||||||||||||||||||
Version number | 2 |