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Cellosaurus CI-hAELVi (CVCL_C1M0)

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Cell line name CI-hAELVi
Synonyms hAELVi.A; human Alveolar Epithelial Lentivirus immortalized clone A
Accession CVCL_C1M0
Resource Identification Initiative To cite this cell line use: CI-hAELVi (RRID:CVCL_C1M0)
Comments Characteristics: Suitable to model the air-blood barrier of the peripheral lung. Forms tight intercellular junctions, with high trans-epithelial electrical resistance (PubMed=26985677).
Characteristics: Transduced with a lentiviral library consisting of 33 genes, some of which are retained in the immortalized cell line (CI-SCREEN) (PubMed=26985677).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5361; ID2.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5362; ID3.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:7553; MYC.
Genetic integration: Method=Transduction; Gene=MGI; MGI:88138; Bcl2.
Genetic integration: Method=Transduction; Gene=MGI; MGI:1919200; Nanog.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=Hepatitis C virus core protein.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Lung, alveolus; UBERON=UBERON_0002299.
Cell type: Type 1 pneumocyte; CL=CL_0002062.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E6BF (CI-huArlo)
Originate from same individual CVCL_C1M1 ! hAELVi.B
Sex of cell Male
Age at sampling Age unspecified
Category Transformed cell line
STR profile Source(s): InSCREENeX=INS-CI-1015

Markers:
AmelogeninX,Y
CSF1PO10,13
D2S133817
D3S135815,17
D5S81811
D7S82011
D8S117914,15
D13S31710,12
D16S53911
D18S5115,16
D19S43313,13.2
D21S1130.2,33.2
FGA23
TH019
TPOX8
vWA17,18

Run an STR similarity search on this cell line
Web pages Provider; InSCREENeX; INS-CI-1015; https://www.inscreenex.de/product/ci-haelvi/
Publications

PubMed=26985677; DOI=10.14573/altex.1511131
Anna Kuehn, Stephanie Kletting, Cristiane de Souza Carvalho-Wodarz, Urska Repnik, Gareth Wyn Griffiths, Ulrike Fischer, Eckart U. Meese, Hanno Huwer, Dagmar Wirth, Tobias May, Nicole Schneider-Daum, Claus-Michael Lehr;
Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier.
ALTEX 33:251-260(2016)

PubMed=36748276; DOI=10.1002/advs.202207301; PMCID=PMC10015904
Patrick Carius, Annemarie Jungmann, Marco Bechtel, Alexander Grissmer, Annette Boese, Gilles Gasparoni, Abdulrahman Salhab, Ralf Seipelt, Klaus Urbschat, Clementine Richter, Carola Meier ...Show all 16 authors... , Denisa Bojkova, Jindrich Cinatl Jr., Jorn Walter, Nicole Schneider-Daum, Claus-Michael Lehr; Show fewer authors
A monoclonal human alveolar epithelial cell line ('Arlo') with pronounced barrier function for studying drug permeability and viral infections.
Adv. Sci. (Weinh.) 10:2207301.1-2207301.23(2023)

Cross-references
Encyclopedic resources Wikidata; Q114311559
Entry history
Entry creation22-Sep-2022
Last entry update10-Apr-2025
Version number7