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Cellosaurus hAELVi.B (CVCL_C1M1)

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Cell line name hAELVi.B
Synonyms human Alveolar Epithelial Lentivirus immortalized clone B
Accession CVCL_C1M1
Resource Identification Initiative To cite this cell line use: hAELVi.B (RRID:CVCL_C1M1)
Comments Characteristics: Suitable to model the air-blood barrier of the peripheral lung. Forms tight intercellular junctions, with high trans-epithelial electrical resistance (PubMed=26985677).
Characteristics: Transduced with a lentiviral library consisting of 33 genes, some of which are retained in the immortalized cell line (CI-SCREEN).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5361; ID2.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5362; ID3.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:7553; MYC.
Genetic integration: Method=Transduction; Gene=MGI; MGI:88138; Bcl2.
Genetic integration: Method=Transduction; Gene=MGI; MGI:1919200; Nanog.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=Hepatitis C virus core protein.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Lung, alveolus; UBERON=UBERON_0002299.
Cell type: Type 1 pneumocyte; CL=CL_0002062.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_C1M0 ! CI-hAELVi
Sex of cell Male
Age at sampling Age unspecified
Category Transformed cell line
Publications

PubMed=26985677; DOI=10.14573/altex.1511131
Anna Kuehn, Stephanie Kletting, Cristiane de Souza Carvalho-Wodarz, Urska Repnik, Gareth Wyn Griffiths, Ulrike Fischer, Eckart U. Meese, Hanno Huwer, Dagmar Wirth, Tobias May, Nicole Schneider-Daum, Claus-Michael Lehr;
Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier.
ALTEX 33:251-260(2016)

PubMed=29169185; DOI=10.14573/altex.1607191
Stephanie Kletting, Sarah Barthold, Urska Repnik, Gareth Wyn Griffiths, Brigitta Loretz, Nicole Schneider-Daum, Cristiane de Souza Carvalho-Wodarz, Claus-Michael Lehr;
Co-culture of human alveolar epithelial (hAELVi) and macrophage (THP-1) cell lines.
ALTEX 35:211-222(2018)

Cross-references
Encyclopedic resources Wikidata; Q114311561
Entry history
Entry creation22-Sep-2022
Last entry update10-Apr-2025
Version number7