ID   CI-hAELVi
AC   CVCL_C1M0
SY   hAELVi.A; human Alveolar Epithelial Lentivirus immortalized clone A
DR   Wikidata; Q114311559
RX   PubMed=26985677;
RX   PubMed=36748276;
WW   Provider; InSCREENeX; INS-CI-1015; https://www.inscreenex.de/product/ci-haelvi/
CC   Characteristics: Suitable to model the air-blood barrier of the peripheral lung. Forms tight intercellular junctions, with high trans-epithelial electrical resistance (PubMed=26985677).
CC   Characteristics: Transduced with a lentiviral library consisting of 33 genes, some of which are retained in the immortalized cell line (CI-SCREEN) (PubMed=26985677).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5361; ID2.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5362; ID3.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:7553; MYC.
CC   Genetic integration: Method=Transduction; Gene=MGI; MGI:88138; Bcl2.
CC   Genetic integration: Method=Transduction; Gene=MGI; MGI:1919200; Nanog.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=Hepatitis C virus core protein.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Derived from site: In situ; Lung, alveolus; UBERON=UBERON_0002299.
CC   Cell type: Type 1 pneumocyte; CL=CL_0002062.
ST   Source(s): InSCREENeX=INS-CI-1015
ST   Amelogenin: X,Y
ST   CSF1PO: 10,13
ST   D13S317: 10,12
ST   D16S539: 11
ST   D18S51: 15,16
ST   D19S433: 13,13.2
ST   D21S11: 30.2,33.2
ST   D2S1338: 17
ST   D3S1358: 15,17
ST   D5S818: 11
ST   D7S820: 11
ST   D8S1179: 14,15
ST   FGA: 23
ST   TH01: 9
ST   TPOX: 8
ST   vWA: 17,18
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_C1M1 ! hAELVi.B
SX   Male
AG   Age unspecified
CA   Transformed cell line
DT   Created: 22-09-22; Last updated: 10-04-25; Version: 7
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RX   PubMed=26985677; DOI=10.14573/altex.1511131;
RA   Kuehn A., Kletting S., de Souza Carvalho-Wodarz C., Repnik U.,
RA   Griffiths G.W., Fischer U., Meese E.U., Huwer H., Wirth D., May T.,
RA   Schneider-Daum N., Lehr C.-M.;
RT   "Human alveolar epithelial cells expressing tight junctions to model
RT   the air-blood barrier.";
RL   ALTEX 33:251-260(2016).
//
RX   PubMed=36748276; DOI=10.1002/advs.202207301; PMCID=PMC10015904;
RA   Carius P., Jungmann A., Bechtel M., Grissmer A., Boese A., Gasparoni G.,
RA   Salhab A., Seipelt R., Urbschat K., Richter C., Meier C., Bojkova D.,
RA   Cinatl J. Jr., Walter J., Schneider-Daum N., Lehr C.-M.;
RT   "A monoclonal human alveolar epithelial cell line ('Arlo') with
RT   pronounced barrier function for studying drug permeability and viral
RT   infections.";
RL   Adv. Sci. (Weinh.) 10:2207301.1-2207301.23(2023).
//