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Cellosaurus PC12-27 (CVCL_C0PV)

[Text version]
Cell line name PC12-27
Synonyms PC 12-27; PC12 clone 27
Accession CVCL_C0PV
Resource Identification Initiative To cite this cell line use: PC12-27 (RRID:CVCL_C0PV)
Comments Characteristics: Fully incompetent for both branches of regulated secretion, those of dense granules and synaptic-like microvesicles, possibly because of the impairment of a general expression control system that appears to operate independently of neuroendocrine cell differentiation (PubMed=8900203).
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Adrenal gland; UBERON=UBERON_0002369.
Disease Rat adrenal gland pheochromocytoma (NCIt: C121568)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: NEDH.
Hierarchy Parent: CVCL_0481 (PC12)
CVCL_C0PW (PC12-27 c7)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line

PubMed=1657914; DOI=10.1016/S0021-9258(18)54903-6
Zacchetti D., Clementi E., Fasolato C., Lorenzon P., Zottini M., Grohovaz F., Fumagalli G., Pozzan T., Meldolesi J.
Intracellular Ca2+ pools in PC12 cells. A unique, rapidly exchanging pool is sensitive to both inositol 1,4,5-trisphosphate and caffeine-ryanodine.
J. Biol. Chem. 266:20152-20158(1991)

PubMed=12106430; DOI=10.1111/j.1460-9568.1992.tb00121.x
Clementi E., Racchetti G., Zacchetti D., Panzeri M.C., Meldolesi J.
Differential expression of markers and activities in a group of PC12 nerve cell clones.
Eur. J. Neurosci. 4:944-953(1992)

PubMed=8900203; DOI=10.1074/jbc.271.43.27116
Corradi N., Borgonovo B., Clementi E., Bassetti M., Racchetti G., Consalez G.G., Huttner W.B., Meldolesi J., Rosa P.
Overall lack of regulated secretion in a PC12 variant cell clone.
J. Biol. Chem. 271:27116-27124(1996)

PubMed=9856988; DOI=10.1074/jbc.273.52.34683
Borgonovo B., Racchetti G., Malosio M.L., Benfante R., Podini P., Rosa P., Meldolesi J.
Neurosecretion competence, an independently regulated trait of the neurosecretory cell phenotype.
J. Biol. Chem. 273:34683-34686(1998)

PubMed=9933147; DOI=10.1007/pl00005319
Arslan G., Kull B., Fredholm B.B.
Signaling via A2A adenosine receptor in four PC12 cell clones.
Naunyn Schmiedebergs Arch. Pharmacol. 359:28-32(1999)

PubMed=10517799; DOI=10.1111/j.1469-7793.1999.t01-1-00043.x
Malosio M.L., Benfante R., Racchetti G., Borgonovo B., Rosa P., Meldolesi J.
Neurosecretory cells without neurosecretion: evidence of an independently regulated trait of the cell phenotype.
J. Physiol. (Lond.) 520:43-52(1999)

Cell line databases/resources TOKU-E; 3553
Encyclopedic resources Wikidata; Q112930276
Entry history
Entry creation23-Jun-2022
Last entry update29-Jun-2023
Version number5