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Cellosaurus MC-38 (CVCL_B288)

[Text version]
Cell line name MC-38
Synonyms MCA-38; MCA 38; MCA38; MC38; Mouse Colon 38; Murine Carcinoma-38; Colon-38; Colon 38; Colon38; C38
Accession CVCL_B288
Resource Identification Initiative To cite this cell line use: MC-38 (RRID:CVCL_B288)
Comments Doubling time: 24.3 hours (PubMed=16320114).
Omics: Genomics; Mitochondrial genome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Caution: The authors of PubMed=25434994 indicate that they have sequenced the mitochondrial genome of the 'rat' cell line MCA38. Their submitted DNA sequence (KM820832.1) is indeed a rat sequence but is labelled as originating from 'rat isolate 406'.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Disease Mouse colon adenocarcinoma (NCIt: C120044)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Children:
CVCL_E6WA (Genomeditech MC-38 H_AMHR2)CVCL_E6WB (Genomeditech MC-38 H_CD24)CVCL_E6WC (Genomeditech MC-38 H_CD274(PD-L1))
CVCL_E6WD (Genomeditech MC-38 H_CD47)CVCL_E6WE (Genomeditech MC-38 H_CEACAM5(CEA))CVCL_E6WF (Genomeditech MC-38 H_CLDN18(isoform 2))
CVCL_E6WG (Genomeditech MC-38 H_ERBB2(HER2))CVCL_E6WH (Genomeditech MC-38 H_ERBB2(HER2)+ERBB3(HER3))CVCL_E6WI (Genomeditech MC-38 H_ERBB3(HER3))
CVCL_E6WJ (Genomeditech MC-38 H_GPRC5D)CVCL_E6WK (Genomeditech MC-38 H_HLA-G+B2M)CVCL_E6WL (Genomeditech MC-38 H_SIGLEC15+TYROBP)
CVCL_E1LY (HyCyte MC-38 KO-mCasp8)CVCL_E1LZ (HyCyte MC-38 KO-mCd274)CVCL_D6C1 (HyCyte MC-38 KO-mCxcl9)
CVCL_E1M0 (HyCyte MC-38 KO-mFmr1)CVCL_D6C2 (HyCyte MC-38 KO-mMdm4)CVCL_E1M1 (HyCyte MC-38 KO-mPrmt3)
CVCL_D6C3 (HyCyte MC-38 KO-mStk11)CVCL_E3HX (HyCyte MC-38-Luc)CVCL_D0P4 (MC-38 B2m-KO)
CVCL_5I36 (MC-38-CEA-1)CVCL_5I37 (MC-38-CEA-2)CVCL_5I38 (MC-38-MUC-1)
CVCL_XZ58 (MC38 human PDL1)CVCL_C8VZ (MC38-Luc)CVCL_B7NQ (MC38-Luc-RFP)
CVCL_B7NM (MC38-PD-L1 KO)CVCL_XJ96 (MC38-OVA)CVCL_0A68 (MC38/0)
CVCL_0A67 (MC38Luc1)CVCL_B9CM (MC38Luc4)CVCL_B9CN (MC38Luc8)
CVCL_D7FA (SL4)CVCL_E0XJ (Ubigene MC-38 Alkbh1 KO)CVCL_E0XK (Ubigene MC-38 Arid1a KO)
CVCL_E0XL (Ubigene MC-38 Arid2 KO)CVCL_E0XM (Ubigene MC-38 Atrx KO)CVCL_E0XN (Ubigene MC-38 B2m KO)
CVCL_E0XP (Ubigene MC-38 Cd274 KO)CVCL_E0XQ (Ubigene MC-38 Cd276 KO)CVCL_E0XR (Ubigene MC-38 Cd38 KO)
CVCL_E0XS (Ubigene MC-38 Cd47 KO)CVCL_E0XT (Ubigene MC-38 Epha2 KO)CVCL_E0XU (Ubigene MC-38 Erbb2 KO)
CVCL_E0XW (Ubigene MC-38 Fat1 KO)CVCL_E0XX (Ubigene MC-38 Il1r1 KO)CVCL_E0XY (Ubigene MC-38 Kmt2c KO)
CVCL_E0XZ (Ubigene MC-38 Kmt2d KO)CVCL_E0Y0 (Ubigene MC-38 Lrpprc KO)CVCL_E0Y1 (Ubigene MC-38 Mif KO)
CVCL_E0Y2 (Ubigene MC-38 Rb1 KO)CVCL_E0Y3 (Ubigene MC-38 Siglec15 KO)CVCL_E0Y4 (Ubigene MC-38 Tnfrsf10b KO)
CVCL_E0Y5 (Ubigene MC-38 Tnfrsf14 KO)CVCL_E0Y6 (Ubigene MC-38 Tnfrsf17 KO)CVCL_E0Y7 (Ubigene MC-38 Tnfrsf1b KO)
CVCL_E0Y8 (Ubigene MC-38 Ythdf1 KO)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Millipore=SCC172; Ubigene=YC-A002

Markers:
Mouse STR 1-115,16,17
Mouse STR 1-218,19,20
Mouse STR 2-116
Mouse STR 3-214,15
Mouse STR 4-220.3
Mouse STR 5-516,17 (Ubigene=YC-A002)
17 (Millipore=SCC172)
Mouse STR 6-417,18 (Millipore=SCC172)
18 (Ubigene=YC-A002)
Mouse STR 6-715,16
Mouse STR 7-126.2
Mouse STR 8-116
Mouse STR 11-216
Mouse STR 12-116,17,18 (Millipore=SCC172)
17 (Ubigene=YC-A002)
Mouse STR 13-117
Mouse STR 15-322.3 (Millipore=SCC172)
22.3,23.3 (Ubigene=YC-A002)
Mouse STR 17-215,16
Mouse STR 18-315,16
Mouse STR 19-213
Mouse STR X-127

Run an STR similarity search on this cell line
Web pages Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/colon-cancer-xenograft/mc38-xenograft-model/
Publications

PubMed=1149045
Corbett T.H., Griswold D.P. Jr., Roberts B.J., Peckham J.C., Schabel F.M. Jr.
Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure.
Cancer Res. 35:2434-2439(1975)

PubMed=1255804; DOI=10.1093/jnci/56.4.871
Tan M.H., Holyoke E.D., Goldrosen M.H.
Murine colon adenocarcinomas: methods for selective culture in vitro.
J. Natl. Cancer Inst. 56:871-873(1976)

PubMed=16320114; DOI=10.1007/s10585-005-3585-0
Morimoto-Tomita M., Ohashi Y., Matsubara A., Tsuiji M., Irimura T.
Mouse colon carcinoma cells established for high incidence of experimental hepatic metastasis exhibit accelerated and anchorage-independent growth.
Clin. Exp. Metastasis 22:513-521(2005)

PubMed=25277546; DOI=10.1186/1471-2164-15-847; PMCID=PMC4198738
Didion J.P., Buus R.J., Naghashfar Z., Threadgill D.W., Morse H.C. 3rd, Pardo-Manuel de Villena F.
SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy.
BMC Genomics 15:847.1-847.11(2014)

PubMed=25434994; DOI=10.3109/19401736.2014.974176
Zhang C.-F., Yu X.-J., Wang B.-Y., Chen H.-W., Hu C.-E.
Whole mitochondrial genome sequence of a rat colorectal cancer MCA38 cell line.
Mitochondrial DNA A. DNA Mapp. Seq. Anal. 27:2034-2035(2016)

Cross-references
Cell line collections (Providers) ABM; T8291
CLS; 305223 - Discontinued
Kerafast; ENH204-FP
Millipore; SCC172
Ubigene; YC-A002
Cell line databases/resources CCRID; 1101MOU-PUMC000523
Lonza; 893
Anatomy/cell type resources BTO; BTO_0004163
Chemistry resources ChEMBL-Cells; CHEMBL3307696
ChEMBL-Targets; CHEMBL612821
PubChem_Cell_line; CVCL_B288
Encyclopedic resources Wikidata; Q54904168
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number25