Home  |  Contact

Cellosaurus KBM-7/B5 (CVCL_B254)

[Text version]

Cell line name KBM-7/B5
Synonyms KBM-7-B5; KBM7B5
Accession CVCL_B254
Resource Identification Initiative To cite this cell line use: KBM-7/B5 (RRID:CVCL_B254)
Comments Group: Haploid karyotype cell line.
Karyotypic information: Haploid except for a disomy of chromosome 8.
Derived from sampling site: Bone marrow.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A426 (KBM-7)
Children:
CVCL_8Z14 (KBM-7/B5-1803 )
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line
Publications

PubMed=8609723
Andersson B.S., Collins V.P., Kurzrock R., Larkin D.W., Childs C., Ost A., Cork A., Trujillo J.M., Freireich E.J., Siciliano M.J., Deisseroth A.B.
KBM-7, a human myeloid leukemia cell line with double Philadelphia chromosomes lacking normal c-ABL and BCR transcripts.
Leukemia 9:2100-2108(1995)

PubMed=9783811; DOI=10.1016/S0145-2126(98)00093-9
Munker R., Zhao S., Jiang S., Snell V., Andreeff M., Andersson B.S.
Further characterization of cyclophosphamide resistance: expression of CD95 and of bcl-2 in a CML cell line.
Leuk. Res. 22:1073-1077(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

Cross-references
Encyclopedic resources Wikidata; Q54899587
Entry history
Entry creation06-Jun-2012
Last entry update23-Sep-2021
Version number17