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Cellosaurus KBM-7/B5 (CVCL_B254)

[Text version]

Cell line name KBM-7/B5
Synonyms KBM-7-B5; KBM7B5
Accession CVCL_B254
Resource Identification Initiative To cite this cell line use: KBM-7/B5 (RRID:CVCL_B254)
Comments Group: Haploid karyotype cell line.
Karyotypic information: Haploid except for a disomy of chromosome 8.
Derived from sampling site: Bone marrow.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A426 (KBM-7)
CVCL_8Z14 (KBM-7/B5-1803 )
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line

Andersson B.S., Collins V.P., Kurzrock R., Larkin D.W., Childs C., Ost A., Cork A., Trujillo J.M., Freireich E.J., Siciliano M.J., Deisseroth A.B.
KBM-7, a human myeloid leukemia cell line with double Philadelphia chromosomes lacking normal c-ABL and BCR transcripts.
Leukemia 9:2100-2108(1995)

PubMed=9783811; DOI=10.1016/S0145-2126(98)00093-9
Munker R., Zhao S., Jiang S., Snell V., Andreeff M., Andersson B.S.
Further characterization of cyclophosphamide resistance: expression of CD95 and of bcl-2 in a CML cell line.
Leuk. Res. 22:1073-1077(1998)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

Encyclopedic resources Wikidata; Q54899587
Entry history
Entry creation06-Jun-2012
Last entry update23-Sep-2021
Version number17