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Cellosaurus KBM-7/B5-1803 (CVCL_8Z14)

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Cell line name KBM-7/B5-1803
Synonyms KBM7-B5-1803; KBM-7/B5 clone 1803
Accession CVCL_8Z14
Resource Identification Initiative To cite this cell line use: KBM-7/B5-1803 (RRID:CVCL_8Z14)
Comments Group: Haploid karyotype cell line.
Karyotypic information: Haploid except for a disomy of chromosome 8.
Selected for resistance to: ChEBI; CHEBI_4027; Cyclophosphamide (CP; Endoxan).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B254 (KBM-7/B5)
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line
Publications

PubMed=9783811; DOI=10.1016/S0145-2126(98)00093-9
Reinhold Munker, Shou-Rong Zhao, Shu-Wei Jiang, Virginia Snell, Michael Andreeff, Borje S. Andersson;
Further characterization of cyclophosphamide resistance: expression of CD95 and of bcl-2 in a CML cell line.
Leuk. Res. 22:1073-1077(1998)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8Z14
Encyclopedic resources Wikidata; Q54899588
Entry history
Entry creation23-Feb-2016
Last entry update19-Dec-2024
Version number17