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Cellosaurus KBM-7 (CVCL_A426)

[Text version]

Cell line name KBM-7
Synonyms KBM7; KBM-7/Hap8
Accession CVCL_A426
Resource Identification Initiative To cite this cell line use: KBM-7 (RRID:CVCL_A426)
Comments Group: Haploid karyotype cell line.
Doubling time: 22 hours (PubMed=8609723).
Karyotypic information: Haploid except for a disomy of chromosome 8.
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: SNP array analysis.
Misspelling: KMB-7; Occasionally.
Derived from sampling site: Bone marrow.
Sequence variations
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_Y019 (HAP1 )CVCL_B253 (KBM-7 P1-55 )CVCL_B254 (KBM-7/B5 )
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line
STR profile Source(s): PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10
D3S135815
D5S81812
D7S8209
D8S11798,14
D13S31711
D16S53911
D18S5118
D21S1130
FGA21
Penta D9
Penta E10
TH017
TPOX8
vWA18

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/KBM-7_cells
Publications

PubMed=7627932; DOI=10.1016/0165-4608(94)00282-g
Sen S., Zhou H.-Y., Andersson B.S., Cork A., Freireich E.J., Stass S.A.
p53 gene mutations with chromosome 17 abnormalities in chronic myelogenous leukemia blast crisis patients persist in long-term cell lines but may be acquired in acute myeloid leukemia cells in vitro.
Cancer Genet. Cytogenet. 82:35-40(1995)

PubMed=8609723
Andersson B.S., Collins V.P., Kurzrock R., Larkin D.W., Childs C., Ost A., Cork A., Trujillo J.M., Freireich E.J., Siciliano M.J., Deisseroth A.B.
KBM-7, a human myeloid leukemia cell line with double Philadelphia chromosomes lacking normal c-ABL and BCR transcripts.
Leukemia 9:2100-2108(1995)

PubMed=10071072; DOI=10.1016/s0145-2126(98)00171-4
Drexler H.G., MacLeod R.A.F., Uphoff C.C.
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=23861985; DOI=10.1371/journal.pone.0070339
Lee C.C., Carette J.E., Brummelkamp T.R., Ploegh H.L.
A reporter screen in a human haploid cell line identifies CYLD as a constitutive inhibitor of NF-kappaB.
PLoS ONE 8:E70339-E70339(2013)

PubMed=24161985; DOI=10.1038/nmeth.2609
Burckstummer T., Banning C., Hainzl P., Schobesberger R., Kerzendorfer C., Pauler F.M., Chen D., Them N., Schischlik F., Rebsamen M., Smida M., Fece de la Cruz F., Lapao A., Liszt M., Eizinger B., Guenzl P.M., Blomen V.A., Konopka T., Gapp B.V., Parapatics K., Maier B., Stockl J., Fischl W., Salic S., Taba Casari M.R., Knapp S., Bennett K.L., Bock C., Colinge J., Kralovics R., Ammerer G., Casari G., Brummelkamp T.R., Superti-Furga G., Nijman S.M.B.
A reversible gene trap collection empowers haploid genetics in human cells.
Nat. Methods 10:965-971(2013)

PubMed=24644259; DOI=10.1242/dev.102202
Wutz A.
Haploid animal cells.
Development 141:1423-1426(2014)

PubMed=29474001; DOI=10.1002/pmic.201700386
Lee S.-E., Song J., Bosl K., Muller A.C., Vitko D., Bennett K.L., Superti-Furga G., Pandey A., Kandasamy R.K., Kim M.S.
Proteogenomic analysis to identify missing proteins from haploid cell lines.
Proteomics 18:1700386.1-1700386.9(2018)

Cross-references
Cell line collections Horizon_Discovery; C628
Anatomy/cell type resources BTO; BTO:0005775
Biological sample resources 4DN; 4DNSRYBIH9HS
BioSample; SAMN03473259
ENCODE; ENCBS322FGS
ENCODE; ENCBS815EDC
Encyclopedic resources Wikidata; Q18392835
Experimental variables resources EFO; EFO_0005903
Polymorphism and mutation databases Cosmic; 787496
IARC_TP53; 4653
Proteomic databases PRIDE; PXD006614
Entry history
Entry creation06-Jun-2012
Last entry update23-Sep-2021
Version number20