ID   KBM-7
AC   CVCL_A426
SY   KBM7; KBM-7/Hap8
DR   BTO; BTO_0005775
DR   EFO; EFO_0005903
DR   4DN; 4DNSRYBIH9HS
DR   BioGRID_ORCS_Cell_line; 43
DR   BioSample; SAMN03473259
DR   cancercelllines; CVCL_A426
DR   Cosmic; 787496
DR   ENCODE; ENCBS322FGS
DR   ENCODE; ENCBS815EDC
DR   Horizon_Discovery; C628
DR   IARC_TP53; 4653
DR   PRIDE; PXD006614
DR   Wikidata; Q18392835
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=7627932;
RX   PubMed=8609723;
RX   PubMed=10071072;
RX   PubMed=10576511;
RX   PubMed=23861985;
RX   PubMed=24161985;
RX   PubMed=24644259;
RX   PubMed=25877200;
RX   PubMed=29474001;
WW   Info; Wikipedia; -; https://en.wikipedia.org/wiki/KBM-7_cells
WW   Provider; Tufts TTIC; T001034; https://viceprovost.tufts.edu/research-tool-cell-line-near-haploid-mammalian-cell-line
CC   Group: Haploid karyotype cell line.
CC   Doubling time: 22 hours (PubMed=8609723).
CC   Karyotypic information: Haploid except for a disomy of chromosome 8.
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (PubMed=8609723; PubMed=10071072; PubMed=10576511).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (PubMed=7627932; PubMed=24161985).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics.
CC   Omics: Variations; SNP array analysis.
CC   Misspelling: KMB-7; Note=Occasionally.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 11
ST   D16S539: 11
ST   D18S51: 18
ST   D21S11: 30
ST   D3S1358: 15
ST   D5S818: 12
ST   D7S820: 9
ST   D8S1179: 8,14
ST   FGA: 21
ST   Penta D: 9
ST   Penta E: 10
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 18
DI   NCIt; C3174; Chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   40Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 27
CH   CVCL_Y019 ! HAP1
CH   CVCL_B253 ! KBM-7 P1-55
CH   CVCL_B254 ! KBM-7/B5
//
RX   PubMed=23861985; DOI=10.1371/journal.pone.0070339; PMCID=PMC3704534;
RA   Lee, Clarissa C.
RA   Carette, Jan E.
RA   Brummelkamp, Thijn R.
RA   Ploegh, Hidde Lolke
RT   "A reporter screen in a human haploid cell line identifies CYLD as a
RT   constitutive inhibitor of NF-kappaB.";
RL   PLoS ONE 8:e70339.1-e70339.8(2013).
//
RX   PubMed=29474001; DOI=10.1002/pmic.201700386;
RA   Lee, Seung-Eun
RA   Song, JongKeon
RA   Bosl, Korbinian
RA   Muller, Andre C.
RA   Vitko, Dijana
RA   Bennett, Keiryn L.
RA   Superti-Furga, Giulio
RA   Pandey, Akhilesh
RA   Kandasamy, Richard Kumaran
RA   Kim, Min Sung
RT   "Proteogenomic analysis to identify missing proteins from haploid cell
RT   lines.";
RL   Proteomics 18:e1700386.1-e1700386.9(2018).
//
RX   PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9;
RA   Uphoff, Cord C.
RA   Habig, Silke
RA   Fombonne, Severine
RA   Matsuo, Yoshinobu
RA   Drexler, Hans Gunther
RT   "ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";
RL   Leuk. Res. 23:1055-1060(1999).
//
RX   PubMed=7627932; DOI=10.1016/0165-4608(94)00282-g;
RA   Sen, Subrata
RA   Zhou, Hong-Yi
RA   Andersson, Borje S.
RA   Cork, Ann
RA   Freireich, Emil J.
RA   Stass, Sanford Alvin
RT   "p53 gene mutations with chromosome 17 abnormalities in chronic
RT   myelogenous leukemia blast crisis patients persist in long-term cell
RT   lines but may be acquired in acute myeloid leukemia cells in vitro.";
RL   Cancer Genet. Cytogenet. 82:35-40(1995).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4;
RA   Drexler, Hans Gunther
RA   MacLeod, Roderick A.F.
RA   Uphoff, Cord C.
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=24161985; DOI=10.1038/nmeth.2609; PMCID=PMC6342250;
RA   Burckstummer, Tilmann
RA   Banning, Carina
RA   Hainzl, Philipp
RA   Schobesberger, Richard
RA   Kerzendorfer, Claudia
RA   Pauler, Florian M.
RA   Chen, Doris
RA   Them, Nicole
RA   Schischlik, Fiorella
RA   Rebsamen, Manuele
RA   Smida, Michal
RA   Fece de la Cruz, Ferran
RA   Lapao, Ana
RA   Liszt, Melissa
RA   Eizinger, Benjamin
RA   Guenzl, Philipp M.
RA   Blomen, Vincent A.
RA   Konopka, Tomasz
RA   Gapp, Bianca V.
RA   Parapatics, Katja
RA   Maier, Barbara
RA   Stockl, Johannes
RA   Fischl, Wolfgang
RA   Salic, Sejla
RA   Taba Casari, M. Rita
RA   Knapp, Sylvia
RA   Bennett, Keiryn L.
RA   Bock, Christoph
RA   Colinge, Jacques
RA   Kralovics, Robert
RA   Ammerer, Gustav
RA   Casari, Georg
RA   Brummelkamp, Thijn R.
RA   Superti-Furga, Giulio
RA   Nijman, Sebastian M.B.
RT   "A reversible gene trap collection empowers haploid genetics in human
RT   cells.";
RL   Nat. Methods 10:965-971(2013).
//
RX   PubMed=24644259; DOI=10.1242/dev.102202;
RA   Wutz, Anton
RT   "Haploid animal cells.";
RL   Development 141:1423-1426(2014).
//
RX   PubMed=8609723;
RA   Andersson, Borje S.
RA   Collins, Vincent Peter
RA   Kurzrock, Razelle
RA   Larkin, David W.
RA   Childs, Craig
RA   Ost, Ake
RA   Cork, Ann
RA   Trujillo, Jose M.
RA   Freireich, Emil J.
RA   Siciliano, Michael Joseph
RA   Deisseroth, Albert Ballman
RT   "KBM-7, a human myeloid leukemia cell line with double Philadelphia
RT   chromosomes lacking normal c-ABL and BCR transcripts.";
RL   Leukemia 9:2100-2108(1995).
//