ID   KBM-7
AC   CVCL_A426
SY   KBM7; KBM-7/Hap8
DR   BTO; BTO:0005775
DR   EFO; EFO_0005903
DR   4DN; 4DNSRYBIH9HS
DR   BioSample; SAMN03473259
DR   Cosmic; 787496
DR   ENCODE; ENCBS322FGS
DR   ENCODE; ENCBS815EDC
DR   Horizon_Discovery; C628
DR   IARC_TP53; 4653
DR   PRIDE; PXD006614
DR   Wikidata; Q18392835
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=7627932;
RX   PubMed=8609723;
RX   PubMed=10071072;
RX   PubMed=23861985;
RX   PubMed=24161985;
RX   PubMed=24644259;
RX   PubMed=29474001;
WW   https://en.wikipedia.org/wiki/KBM-7_cells
CC   Group: Haploid karyotype cell line.
CC   Doubling time: 22 hours (PubMed=8609723).
CC   Karyotypic information: Haploid except for a disomy of chromosome 8.
CC   Sequence variation: Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (PubMed=8609723; PubMed=10071072).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (PubMed=7627932; PubMed=24161985).
CC   Omics: Deep exome analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: SNP array analysis.
CC   Misspelling: KMB-7; Occasionally.
CC   Derived from sampling site: Bone marrow.
ST   Source(s): PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 11
ST   D16S539: 11
ST   D18S51: 18
ST   D21S11: 30
ST   D3S1358: 15
ST   D5S818: 12
ST   D7S820: 9
ST   D8S1179: 8,14
ST   FGA: 21
ST   Penta D: 9
ST   Penta E: 10
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 18
DI   NCIt; C3174; Chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
AG   40Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 23-09-21; Version: 20
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=7627932; DOI=10.1016/0165-4608(94)00282-g;
RA   Sen S., Zhou H.-Y., Andersson B.S., Cork A., Freireich E.J.,
RA   Stass S.A.;
RT   "p53 gene mutations with chromosome 17 abnormalities in chronic
RT   myelogenous leukemia blast crisis patients persist in long-term cell
RT   lines but may be acquired in acute myeloid leukemia cells in vitro.";
RL   Cancer Genet. Cytogenet. 82:35-40(1995).
//
RX   PubMed=8609723;
RA   Andersson B.S., Collins V.P., Kurzrock R., Larkin D.W., Childs C.,
RA   Ost A., Cork A., Trujillo J.M., Freireich E.J., Siciliano M.J.,
RA   Deisseroth A.B.;
RT   "KBM-7, a human myeloid leukemia cell line with double Philadelphia
RT   chromosomes lacking normal c-ABL and BCR transcripts.";
RL   Leukemia 9:2100-2108(1995).
//
RX   PubMed=10071072; DOI=10.1016/s0145-2126(98)00171-4;
RA   Drexler H.G., MacLeod R.A.F., Uphoff C.C.;
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
//
RX   PubMed=23861985; DOI=10.1371/journal.pone.0070339;
RA   Lee C.C., Carette J.E., Brummelkamp T.R., Ploegh H.L.;
RT   "A reporter screen in a human haploid cell line identifies CYLD as a
RT   constitutive inhibitor of NF-kappaB.";
RL   PLoS ONE 8:E70339-E70339(2013).
//
RX   PubMed=24161985; DOI=10.1038/nmeth.2609;
RA   Burckstummer T., Banning C., Hainzl P., Schobesberger R.,
RA   Kerzendorfer C., Pauler F.M., Chen D., Them N., Schischlik F.,
RA   Rebsamen M., Smida M., Fece de la Cruz F., Lapao A., Liszt M.,
RA   Eizinger B., Guenzl P.M., Blomen V.A., Konopka T., Gapp B.V.,
RA   Parapatics K., Maier B., Stockl J., Fischl W., Salic S.,
RA   Taba Casari M.R., Knapp S., Bennett K.L., Bock C., Colinge J.,
RA   Kralovics R., Ammerer G., Casari G., Brummelkamp T.R.,
RA   Superti-Furga G., Nijman S.M.B.;
RT   "A reversible gene trap collection empowers haploid genetics in human
RT   cells.";
RL   Nat. Methods 10:965-971(2013).
//
RX   PubMed=24644259; DOI=10.1242/dev.102202;
RA   Wutz A.;
RT   "Haploid animal cells.";
RL   Development 141:1423-1426(2014).
//
RX   PubMed=29474001; DOI=10.1002/pmic.201700386;
RA   Lee S.-E., Song J., Bosl K., Muller A.C., Vitko D., Bennett K.L.,
RA   Superti-Furga G., Pandey A., Kandasamy R.K., Kim M.S.;
RT   "Proteogenomic analysis to identify missing proteins from haploid cell
RT   lines.";
RL   Proteomics 18:1700386.1-1700386.9(2018).
//