ID   KBM-7/B5
AC   CVCL_B254
SY   KBM-7-B5; KBM7B5
DR   cancercelllines; CVCL_B254
DR   Wikidata; Q54899587
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=8609723;
RX   PubMed=9783811;
CC   Group: Haploid karyotype cell line.
CC   Karyotypic information: Haploid except for a disomy of chromosome 8.
CC   Sequence variation: Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3174; Chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_A426 ! KBM-7
SX   Male
AG   40Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 20
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RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=8609723;
RA   Andersson B.S., Collins V.P., Kurzrock R., Larkin D.W., Childs C.,
RA   Ost A., Cork A., Trujillo J.M., Freireich E.J., Siciliano M.J.,
RA   Deisseroth A.B.;
RT   "KBM-7, a human myeloid leukemia cell line with double Philadelphia
RT   chromosomes lacking normal c-ABL and BCR transcripts.";
RL   Leukemia 9:2100-2108(1995).
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RX   PubMed=9783811; DOI=10.1016/S0145-2126(98)00093-9;
RA   Munker R., Zhao S.-R., Jiang S.-W., Snell V., Andreeff M.,
RA   Andersson B.S.;
RT   "Further characterization of cyclophosphamide resistance: expression
RT   of CD95 and of bcl-2 in a CML cell line.";
RL   Leuk. Res. 22:1073-1077(1998).
//