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Cellosaurus HCEC 1CT (CVCL_AQ45)

[Text version]
Cell line name HCEC 1CT
Synonyms HCEC-1CT; hCEC-1CT; 1CT-HCEC; Human Colonic Epithelial Cells 1 transduced with CDK4 and Telomerase; 1CT
Accession CVCL_AQ45
Resource Identification Initiative To cite this cell line use: HCEC 1CT (RRID:CVCL_AQ45)
Comments Doubling time: 18-24 hours (Evercyte=CkHT-039-0229).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1773; CDK4.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_AQ46 (HCEC 1CT+7)CVCL_AV01 (HCEC 1CTA)CVCL_AV02 (HCEC 1CTP)
CVCL_AV03 (HCEC 1CTR)
Sex of cell Male
Age at sampling 54Y
Category Telomerase immortalized cell line
STR profile Source(s): PubMed=27047802

Markers:
AmelogeninX,Y
CSF1PO10,12
D5S81811,14
D7S8209,11
D13S31712,13
D16S53910,11
D21S1128
TH019.3
TPOX11
vWA16,18

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Publications

PubMed=19962984; DOI=10.1053/j.gastro.2009.11.052
Andres I. Roig, Ugur Eskiocak, Suzie K. Hight, Sang Bum Kim, Oliver Delgado, Rhonda F. Souza, Stuart J. Spechler, Woodring Erik Wright, Jerry W. Shay;
Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro.
Gastroenterology 138:1012-1021.e215(2010)

PubMed=21472139; DOI=10.1593/neo.101580; PMCID=PMC3071083
Peter Ly, Ugur Eskiocak, Sang Bum Kim, Andres I. Roig, Suzie K. Hight, Dypti R. Lulla, Ying S. Zou, Kimberly G. Batten, Woodring Erik Wright, Jerry W. Shay;
Characterization of aneuploid populations with trisomy 7 and 20 derived from diploid human colonic epithelial cells.
Neoplasia 13:348-357(2011)

PubMed=21527559; DOI=10.1158/0008-5472.CAN-11-0794; PMCID=PMC3326261
Ugur Eskiocak, Sang Bum Kim, Peter Ly, Andres I. Roig, Sebastian Biglione, Kakajan Komurov, Crystal Cornelius, Woodring Erik Wright, Michael A. White, Jerry W. Shay;
Functional parsing of driver mutations in the colorectal cancer genome reveals numerous suppressors of anchorage-independent growth.
Cancer Res. 71:4359-4365(2011)

PubMed=25923178; DOI=10.1186/1471-2164-16-S1-S8; PMCID=PMC4315167
Lu Zhang, Sang Bum Kim, Gao-Xiang Jia, Abdelbaset Buhmeida, Ashraf Dallol, Woodring Erik Wright, Albert J. Fornace Jr., Mohammed Al-Qahtani, Jerry W. Shay;
Exome sequencing of normal and isogenic transformed human colonic epithelial cells (HCECs) reveals novel genes potentially involved in the early stages of colorectal tumorigenesis.
BMC Genomics 16 Suppl. 1:S8.1-S8.8(2015)

PubMed=27047802; DOI=10.3389/fcimb.2016.00034; PMCID=PMC4803749
Vanessa Graillot, Inge Dormoy, Jacques Dupuy, Jerry W. Shay, Laurence Huc, Gladys Mirey, Julien Vignard;
Genotoxicity of cytolethal distending toxin (CDT) on isogenic human colorectal cell lines: potential promoting effects for colorectal carcinogenesis.
Front. Cell. Infect. Microbiol. 6:34.1-34.13(2016)

Cross-references
Cell line collections (Providers) Evercyte; CkHT-039-0229
Biological sample resources ENCODE; ENCBS573VIG
ENCODE; ENCBS654NDM
Encyclopedic resources Wikidata; Q54881860
Experimental variables resources EFO; EFO_0009500
Entry history
Entry creation02-May-2016
Last entry update10-Apr-2025
Version number13