Cellosaurus cell line MDA-MB-435S/1 (CVCL

Cellosaurus MDA-MB-435S/1 (CVCL_A6LJ)

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Cell line name

MDA-MB-435S/1

Synonyms

MDA MB 435 S1; MDA MB 435, subline S1

Accession

CVCL_A6LJ

Resource Identification Initiative

To cite this cell line use: MDA-MB-435S/1 (RRID:CVCL_A6LJ)

Comments

Problematic cell line: Contaminated. Grand-parent cell line (MDA-MB-435) has been shown to be a M14 derivative.
Population: Caucasian.
Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.

Sequence variations

Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).

Disease

Amelanotic melanoma (NCIt: C3802)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0622 (MDA-MB-435S)
Children:

CVCL_6684 (MDA-MB-435HGF)

Sex of cell

Male

Age at sampling

33Y