ID   MDA-MB-435S/1
AC   CVCL_A6LJ
SY   MDA MB 435 S1; MDA MB 435, subline S1
DR   cancercelllines; CVCL_A6LJ
DR   Wikidata; Q107116178
RX   PubMed=2007622;
RX   PubMed=9467938;
CC   Problematic cell line: Contaminated. Grand-parent cell line (MDA-MB-435) has been shown to be a M14 derivative.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0622 ! MDA-MB-435S
SX   Male
AG   33Y
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 05-10-23; Version: 6
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RX   PubMed=2007622; DOI=10.1083/jcb.113.1.173; PMCID=PMC2288921;
RA   Frixen U.H., Behrens J., Sachs M., Eberle G., Voss B., Warda A.,
RA   Lochner D., Birchmeier W.;
RT   "E-cadherin-mediated cell-cell adhesion prevents invasiveness of human
RT   carcinoma cells.";
RL   J. Cell Biol. 113:173-185(1991).
//
RX   PubMed=9467938; DOI=10.1038/sj.onc.1201486;
RA   Meiners S., Brinkmann V., Naundorf H., Birchmeier W.;
RT   "Role of morphogenetic factors in metastasis of mammary carcinoma
RT   cells.";
RL   Oncogene 16:9-20(1998).
//