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Cellosaurus MDA-MB-435HGF (CVCL_6684)

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Cell line name MDA-MB-435HGF
Synonyms MDA-MB-435-HGF; MDA-MB-435 HGF; MDAMB-435-HGF; MDA-MB-HGF; HGF1
Accession CVCL_6684
Resource Identification Initiative To cite this cell line use: MDA-MB-435HGF (RRID:CVCL_6684)
Comments Problematic cell line: Contaminated. Ancestral cell line (MDA-MB-435) has been shown to be a M14 derivative.
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:4893; HGF.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A6LJ (MDA-MB-435S/1)
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
Publications

PubMed=9467938; DOI=10.1038/sj.onc.1201486
Silke Meiners, Volker Brinkmann, Helga Naundorf, Walter Birchmeier;
Role of morphogenetic factors in metastasis of mammary carcinoma cells.
Oncogene 16:9-20(1998)

PubMed=12354931; DOI=10.1136/mp.55.5.294; PMCID=PMC1187258
Gillian Ellison, Teresa Klinowska, R.F. Russell Westwood, E. Docter, Tim French, Jayne Catherine Fox;
Further evidence to support the melanocytic origin of MDA-MB-435.
Mol. Pathol. 55:294-299(2002)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6684
Anatomy/cell type resources BTO; BTO_0004164
Encyclopedic resources Wikidata; Q54904636
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number25