ID   MDA-MB-435HGF
AC   CVCL_6684
SY   MDA-MB-435-HGF; MDA-MB-435 HGF; MDAMB-435-HGF; MDA-MB-HGF; HGF1
DR   BTO; BTO:0004164
DR   cancercelllines; CVCL_6684
DR   Wikidata; Q54904636
RX   PubMed=9467938;
RX   PubMed=12354931;
CC   Problematic cell line: Contaminated. Ancestral cell line (MDA-MB-435) has been shown to be a M14 derivative.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 4893; HGF.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_A6LJ ! MDA-MB-435S/1
SX   Male
AG   33Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-09-24; Version: 23
//
RX   PubMed=9467938; DOI=10.1038/sj.onc.1201486;
RA   Meiners S., Brinkmann V., Naundorf H., Birchmeier W.;
RT   "Role of morphogenetic factors in metastasis of mammary carcinoma
RT   cells.";
RL   Oncogene 16:9-20(1998).
//
RX   PubMed=12354931; DOI=10.1136/mp.55.5.294; PMCID=PMC1187258;
RA   Ellison G., Klinowska T., Westwood R.F.R., Docter E., French T.,
RA   Fox J.C.;
RT   "Further evidence to support the melanocytic origin of MDA-MB-435.";
RL   Mol. Pathol. 55:294-299(2002).
//