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Cellosaurus TMD8 (CVCL_A442)

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Cell line name TMD8
Synonyms TMD-8; Tokyo Medical and Dental university 8
Accession CVCL_A442
Resource Identification Initiative To cite this cell line use: TMD8 (RRID:CVCL_A442)
Comments Population: Japanese.
Characteristics: Genetically heterogeneous, consists of 3 subclones (PubMed=27566572).
Doubling time: ~30 hours (PubMed=16780947).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Miscellaneous: STR profile from personal communication of Gachova, Daniela.
Misspelling: TDM8; PubMed=23292937.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:1699; CD79B; Simple; p.Tyr196His (c.586T>C); Zygosity=Heterozygous (PubMed=20054396).
  • Mutation; HGNC; HGNC:7562; MYD88; Simple; p.Leu252Pro (c.755T>C) (p.Leu265Pro, c.794T>C) (L265P); ClinVar=VCV000037055; Zygosity=Heterozygous (PubMed=21179087).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:07,02:07
HLA-BB*15:01,46:01
HLA-CC*01:02,01:02
Disease Diffuse large B-cell lymphoma activated B-cell type (NCIt: C36081)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E8IZ (TMD8-BTK-A428D-KI-1B4)CVCL_E8J0 (TMD8-BTK-C481F-KI)CVCL_E8J1 (TMD8-BTK-C481S-KI-1B3)
CVCL_E8J2 (TMD8-BTK-C481S-KI-1C6)CVCL_E8J3 (TMD8-BTK-C481Y-KI-1A2)CVCL_E8J4 (TMD8-BTK-C481Y-KI-1B2)
CVCL_E8J5 (TMD8-BTK-HiBiT-KI-1B1)CVCL_E8J6 (TMD8-BTK-L528W-KI)CVCL_E8J7 (TMD8-BTK-T474I-KI-1A1)
CVCL_E8J8 (TMD8-BTK-T474I-KI-1C1)CVCL_E8J9 (TMD8-BTK-V416L-KI-1A3)CVCL_E8JA (TMD8-BTK-V416L-KI-1B1)
CVCL_E8GT (TMD8-Luc2)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133817,23
D3S135817,18
D5S81812,13
D7S8208,10
D8S117910,14
D13S3179,11,12
D16S5399,11
D18S5113,20
D19S43312.2,13.2
D21S1130
FGA17,23
TH016,7
TPOX11
vWA14,18

Run an STR similarity search on this cell line
Publications

PubMed=16780947; DOI=10.1016/j.leukres.2006.05.003
Shuji Tohda, Taku Sato, Hanae Kogoshi, Lu Fu, Seiji Sakano, Nobuo Nara;
Establishment of a novel B-cell lymphoma cell line with suppressed growth by gamma-secretase inhibitors.
Leuk. Res. 30:1385-1390(2006)

PubMed=20054396; DOI=10.1038/nature08638; PMCID=PMC2845535
R. Eric Davis, Vu N. Ngo, Georg Lenz, Pavel Tolar, Ryan M. Young, Paul Bernard Romesser, Holger Kohlhammer, Laurence Lamy, Hong Zhao, Yan-Dan Yang, Wei-Hong Xu ...Show all 37 authors... , Arthur L. Shaffer 3rd, George Wright, Wen-Ming Xiao, John I. Powell, Jian-Kang Jiang, Craig J. Thomas, Andreas Rosenwald, German Ott, Hans-Konrad Muller-Hermelink, Randy D. Gascoyne, Joseph M. Connors, Nathalie A. Johnson, Lisa M. Rimsza, Elias Campo, Elaine Sarkin Jaffe, Wyndham H. Wilson, Jan Delabie, Erlend Bremertun Smeland, Richard I. Fisher, Rita Merle Braziel, Raymond Roy Tubbs, James R. Cook, Dennis D. Weisenburger, Wing-Chung Chan, Susan Keen Pierce, Louis Michael Staudt; Show fewer authors
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma.
Nature 463:88-92(2010)

PubMed=21179087; DOI=10.1038/nature09671; PMCID=PMC5024568
Vu N. Ngo, Ryan M. Young, Roland Schmitz, Sameer Jhavar, Wen-Ming Xiao, Kian-Huat Lim, Holger Kohlhammer, Wei-Hong Xu, Yan-Dan Yang, Hong Zhao, Arthur L. Shaffer 3rd ...Show all 31 authors... , Paul Bernard Romesser, George Wright, John I. Powell, Andreas Rosenwald, Hans-Konrad Muller-Hermelink, German Ott, Randy D. Gascoyne, Joseph M. Connors, Lisa M. Rimsza, Elias Campo, Elaine Sarkin Jaffe, Jan Delabie, Erlend Bremertun Smeland, Richard I. Fisher, Rita Merle Braziel, Raymond Roy Tubbs, James R. Cook, Dennis D. Weisenburger, Wing-Chung Chan, Louis Michael Staudt; Show fewer authors
Oncogenically active MYD88 mutations in human lymphoma.
Nature 470:115-119(2011)

PubMed=23257783; DOI=10.1038/leu.2012.367
Soren-Sebastian Wenzel, Michael Grau, Cory Mavis, Stephan Hailfinger, Annette Wolf, Hannelore Madle, George Deeb, Bernd Dorken, Margot Thome, Peter Lenz, Stefan Dirnhofer ...Show all 14 authors... , Francisco Javier Hernandez-Ilizaliturri, Alexandar Tzankov, Georg Lenz; Show fewer authors
MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma.
Leukemia 27:1381-1390(2013)

PubMed=23292937; DOI=10.1073/pnas.1205299110; PMCID=PMC3557051
Jenny Zhang, Vladimir Grubor, Cassandra L. Love, Anjishnu Banerjee, Kristy L. Richards, Piotr Andrzej Mieczkowski, Cherie Dunphy, William Wai-Lap Choi, Wing Yan Au, Gopesh Srivastava, Patricia Lynne Lugar ...Show all 36 authors... , David A. Rizzieri, Anand S. Lagoo, Leon Bernal-Mizrachi, Karen P. Mann, Christopher Robert Flowers, Kikkeri N. Naresh, Andrew M. Evens, Leo I. Gordon, Magdalena B. Czader, Javed Iqbal Gill, Eric Darryl Hsi, Qing-Quan Liu, Alice Fan, Katherine Walsh, Dereje Jima, Lisa L. Smith, Amy J. Johnson, John C. Byrd, Micah Alan Luftig, Ting Ni, Jun Zhu, Amy Chadburn, Shawn Levy, David Brian Dunson, Sandeep S. Dave; Show fewer authors
Genetic heterogeneity of diffuse large B-cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=26787899; DOI=10.1073/pnas.1524677113; PMCID=PMC4747717
Joseph D. Dekker, Daechan Park, Arthur L. Shaffer 3rd, Holger Kohlhammer, Wei Deng, Bum-Kyu Lee, Gregory C. Ippolito, George Georgiou, Vishwanath R. Iyer, Louis Michael Staudt, Haley O. Tucker;
Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1.
Proc. Natl. Acad. Sci. U.S.A. 113:E577-E586(2016)

PubMed=27566572; DOI=10.18632/oncotarget.11524; PMCID=PMC5325377
Hilmar Quentmeier, Claudia Pommerenke, Ole Ammerpohl, Robert Geffers, Vivien Hauer, Roderick A.F. MacLeod, Stefan Nagel, Julia Romani, Emanuela Rosati, Anders Rosen, Cord C. Uphoff ...Show all 13 authors... , Margarete Zaborski, Hans Gunther Drexler; Show fewer authors
Subclones in B-lymphoma cell lines: isogenic models for the study of gene regulation.
Oncotarget 7:63456-63465(2016)

PubMed=29416618; DOI=10.18632/oncotarget.20378; PMCID=PMC5787470
Wei Liu, Juan Chen, Archito T. Tamayo, Chang-Geng Ruan, Li Li, Shou-Hao Zhou, Chan Shen, Ken H. Young, Jason Westin, Richard E. Davis, Shi-Min Hu ...Show all 14 authors... , L. Jeffrey Medeiros, Richard Joseph Ford Jr., Lan V. Pham; Show fewer authors
Preclinical efficacy and biological effects of the oral proteasome inhibitor ixazomib in diffuse large B-cell lymphoma.
Oncotarget 9:346-360(2018)

PubMed=29666304; DOI=10.1158/1078-0432.CCR-17-3004
Lan V. Pham, Sheng-Jian Huang, Hui Zhang, Jun Zhang, Taylor Bell, Shou-Hao Zhou, Elizabeth Pogue, Zhi-Yong Ding, Laura Lam, Jason Westin, R. Eric Davis ...Show all 17 authors... , Ken H. Young, L. Jeffrey Medeiros, Richard Joseph Ford Jr., Krystle Nomie, Leo Zhang, Michael Wang; Show fewer authors
Strategic therapeutic targeting to overcome venetoclax resistance in aggressive B-cell lymphomas.
Clin. Cancer Res. 24:3967-3980(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A442
CRISP screens repositories BioGRID_ORCS_Cell_line; 748
Chemistry resources ChEMBL-Cells; CHEMBL4295480
ChEMBL-Targets; CHEMBL4296503
PharmacoDB; TMD8_1600_2019
PubChem_Cell_line; CVCL_A442
Encyclopedic resources Wikidata; Q54972694
Experimental variables resources EFO; EFO_0006496
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-4956
GEO; GSM1059801
GEO; GSM1374963
GEO; GSM1527304
GEO; GSM1527305
GEO; GSM1527306
GEO; GSM1527307
GEO; GSM1527308
GEO; GSM1527309
GEO; GSM1890021
GEO; GSM1890022
GEO; GSM1890023
GEO; GSM1890024
GEO; GSM2037048
GEO; GSM2037049
Polymorphism and mutation databases Cosmic; 1486587
Cosmic; 1945194
Cosmic; 2129635
Progenetix; CVCL_A442
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001002554
Entry history
Entry creation06-Jun-2012
Last entry update14-Aug-2025
Version number33